Working…
ClinicalTrials.gov
ClinicalTrials.gov Menu

Changes of Dendritic Cells in Acute Lung Injury

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02083393
Recruitment Status : Completed
First Posted : March 11, 2014
Last Update Posted : May 27, 2015
Sponsor:
Information provided by (Responsible Party):
Jingyuan,Xu, Southeast University, China

Brief Summary:
To observe changes of circulating and tissue dendritic cells in acute lung injury,including invasive aspergillosis pneumonia

Condition or disease
Acute Lung Injury

Detailed Description:
Change of circulating and tissular dendritic cells of patients with acute lung injury was still unclear, we used a flow cytometry-based assay to quantify circulating and tissular DCs and their HLA-DR surface expression at the time of diagnosis and during the first week of evolution in patients with acute lung injury, and healthy people as controls.

Layout table for study information
Study Type : Observational
Actual Enrollment : 19 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Changes of Dendritic Cells in Acute Lung Injury
Study Start Date : June 2011
Actual Primary Completion Date : December 2014
Actual Study Completion Date : December 2014

Resource links provided by the National Library of Medicine


Group/Cohort
Patients with acute lung injury
Patients with sepsis induced acute lung injury
Postsurgery patients
Postsurgery patients without acute lung injury and sepsis



Primary Outcome Measures :
  1. 28-day mortality [ Time Frame: 28day ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Sepsis induced-ALI patients with mechanical ventilation including invasive aspergillosis
Criteria

Inclusion Criteria:

  • Sepsis induced acute lung injury

Exclusion Criteria:

  • Younger than 18-year-old
  • Pregnancy
  • Cancer or organ transplant
  • Asthma
  • COPD
  • Heart Failure

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02083393


Locations
Layout table for location information
China, Jiangsu
Zhongda Hospital Southeast University
Nanjing, Jiangsu, China, 210000
Sponsors and Collaborators
Southeast University, China
Investigators
Layout table for investigator information
Principal Investigator: Haibo Qiu, Ph.D. Southeast University
Layout table for additonal information
Responsible Party: Jingyuan,Xu, Zhongda Hospital, Southeast University, China
ClinicalTrials.gov Identifier: NCT02083393    
Other Study ID Numbers: SoutheastUChina2011ZDllKY04
First Posted: March 11, 2014    Key Record Dates
Last Update Posted: May 27, 2015
Last Verified: May 2015
Keywords provided by Jingyuan,Xu, Southeast University, China:
dendritic cell
Additional relevant MeSH terms:
Layout table for MeSH terms
Lung Injury
Acute Lung Injury
Wounds and Injuries
Lung Diseases
Respiratory Tract Diseases
Thoracic Injuries