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C1q/TNF-related Proteins in Non-Alcoholic Fatty Liver Disease

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ClinicalTrials.gov Identifier: NCT02083159
Recruitment Status : Unknown
Verified September 2016 by Kyung Mook Choi, Korea University.
Recruitment status was:  Recruiting
First Posted : March 11, 2014
Last Update Posted : September 21, 2016
Sponsor:
Information provided by (Responsible Party):
Kyung Mook Choi, Korea University

Brief Summary:

Non-alcoholic fatty liver disease (NAFLD) is characterized by an accumulation of fat in the liver, which is one of the most common forms of chronic liver disease in developed countries. In western countries, the prevalence of NAFLD in the general population is estimated to be 20-30%; in obese populations, this increases to 57.5-74%. But, it hasn't been clearly elucidated yet regarding the underlying disease pathophysiology and treatmet strategy.

Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in glucose metabolism and inflammation.

The investigators tried to clarify the relationship between CTRP family and NAFLD in Korean men and women.


Condition or disease
NAFLD

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Study Type : Observational
Estimated Enrollment : 500 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : March 2012
Estimated Primary Completion Date : December 2016


Group/Cohort
Patients with NAFLD



Primary Outcome Measures :
  1. serum concentration of CTRP-1, 3, or 9 in the subjects with/without NAFLD [ Time Frame: at enrollment ]

Secondary Outcome Measures :
  1. The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles [ Time Frame: at enrollment ]


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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The subjects who visited for a routine health check-up at the Health Promotion Center of Korea University Guro Hospital were enrolled using predefined inclusion and exclusion criteria.
Criteria

Inclusion Criteria:

  • 20<age<80
  • apparently healthy subjects

Exclusion Criteria:

  • a history of CVD
  • diabetes
  • stage 2 hypertension
  • malignancy
  • severe renal or hepatic disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02083159


Contacts
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Contact: Ho Cheol Hong, M.D. 822-2626-3044 naeyo21@naver.com
Contact: Kyung Mook Choi, M.D. 822-2626-3043 medica7@gmail.com

Locations
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Korea, Republic of
Korea Univ. Guro Hospital Recruiting
Seoul, Korea, Republic of
Contact: Ho Cheol Hong, M.D.    822-2626-3044    naeyo21@naver.com   
Contact: Kyung Mook Choi, M.D.    822-2626-3043    medica7@gmail.com   
Sponsors and Collaborators
Korea University
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Responsible Party: Kyung Mook Choi, Professor, Korea University
ClinicalTrials.gov Identifier: NCT02083159    
Other Study ID Numbers: NAFLD(CTRP)
First Posted: March 11, 2014    Key Record Dates
Last Update Posted: September 21, 2016
Last Verified: September 2016