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C1q/TNF-related Proteins in Coronary Artery Disease

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ClinicalTrials.gov Identifier: NCT02083146
Recruitment Status : Terminated (Study subjects were not enrolled.)
First Posted : March 11, 2014
Last Update Posted : March 20, 2018
Sponsor:
Information provided by (Responsible Party):
Kyung Mook Choi, Korea University

Brief Summary:
Now, adipose tissue is established as an active endocrine organ that controls systemic energy homeostasis by secretion of adipokines. Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in metabolism and inflammation. The investigators tried to clarify the relationship between CTRP family and coronary artery disease (CAD) in Korean men and women.

Condition or disease
Coronary Artery Disease (CAD)

Detailed Description:
Adipose tissue secretes various kinds of bioactive molecules termed adipokines which contribute to the development of obesity-related disorders including cardiovascular disease (CVD). Adiponectin is the insulin-sensitizing adipokine with anti-inflammatory and anti-atherogenic properties. Hypoadiponectinemia has been associated with an increased risk of coronary artery disease (CAD) in several though not all studies. Recently, a new family of secreted proteins, C1q/TNF-related protein (CTRP), was cloned on the basis of sequence homology with adiponectin. This family of adiponectin paralogs might have pivotal implications in energy homeostasis and obesity-related inflammation. Each CTRP family member has its own unique tissue expression profile and function in regulating glucose and/or fat metabolism. In the present study, we evaluated the role of CTRP in patients with CAD and investigated whether CTRP family is significantly associated with CAD prevalence after adjustment for well-known CAD risk factors.

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Study Type : Observational
Actual Enrollment : 362 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: C1q/TNF-related Proteins in Coronary Artery Disease
Actual Study Start Date : March 2011
Actual Primary Completion Date : December 2012
Actual Study Completion Date : February 2016

Resource links provided by the National Library of Medicine


Group/Cohort
Patients with CAD
Acute coronary syndromoe (ACS) patients who were admitted to the coronary care unit.



Primary Outcome Measures :
  1. serum concentration of CTRP-1,3, or 9 in the subjects with/without CAD [ Time Frame: at enrollment ]
    compare serum concentration of CTRP-1,3 or 9 between CAD patients and normal group


Secondary Outcome Measures :
  1. The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles [ Time Frame: at enrollment ]
    find the correlation of CTRPs and adiponection with cardiometabolic risk


Biospecimen Retention:   Samples Without DNA
Newly-developed ELISA was used for measurement of CTRP.


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The subjects with stable angina or a history of acute coronary syndrome who visited for a department of cardiology in Korea Univ. Guro hospital were enrolled using predefined inclusion and exclusion criteria.
Criteria

Inclusion Criteria:

  • 20<age<80
  • History of stable angina, unstable angina, or acute myocardial infarction

Exclusion Criteria:

  • a history of diabetes
  • stage 2 hypertension
  • malignancy
  • severe renal or hepatic disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02083146


Locations
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Korea, Republic of
Korea Univ. Guro Hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Korea University
Investigators
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Principal Investigator: Kyung Mook Choi, M.D. medica7@gmail.com
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Responsible Party: Kyung Mook Choi, Professor, Korea University
ClinicalTrials.gov Identifier: NCT02083146    
Other Study ID Numbers: CAD(CTRP)
First Posted: March 11, 2014    Key Record Dates
Last Update Posted: March 20, 2018
Last Verified: March 2018
Additional relevant MeSH terms:
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Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases