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High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation

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ClinicalTrials.gov Identifier: NCT02064361
Recruitment Status : Completed
First Posted : February 17, 2014
Last Update Posted : February 17, 2014
Sponsor:
Collaborator:
University of Maryland, College Park
Information provided by (Responsible Party):
Zeljko Dujic, University Hospital of Split

Brief Summary:
The purpose of this study is to determine the impact of high intensity,anaerobic exercise, in the form of cycling, on SCUBA diving. Outcomes are determined by the quantification and subtype of circulating microparticles, complete blood counts, and the quantification of venous gas emboli, measured via transthoracic echocardiography, in the cardiac cavities.

Condition or disease Intervention/treatment Phase
Decompression Sickness SCUBA Diving Other: High intensity exercise Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 10 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation
Study Start Date : February 2013
Actual Primary Completion Date : May 2013
Actual Study Completion Date : May 2013

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: High intensity exercise
A dive to 18 meters sea water for a duration of 41 minutes preceded by high intensity cycling
Other: High intensity exercise
Subjects performed a repeated Wingate protocol for the exercise condition of the study. This consisted of 4, 30 s maximal efforts on a weight-braked cycle ergometer (Monark 894E, Monark Exercise AB, Sweden) with 4 min active recovery between efforts, preceded by a 5 min warm up. The resistance was set at 7.5% bodyweight for the intervals and 2% for the warm up and active recovery periods.




Primary Outcome Measures :
  1. Change from baseline values of number of circulating microparticles per microliter of blood [ Time Frame: Prior to exercise, prior to diving, 15 and 120 minutes after surfacing ]


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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Experienced divers (> 250 logged dives)
  • Male
  • Physician clearance to dive

Exclusion Criteria:

  • Prior incidence of decompression sickness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02064361


Locations
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United States, Maryland
University of Maryland
Baltimore, Maryland, United States, 21201
Croatia
University of Split School of Medicine
Split, Dalmatia, Croatia, 21000
Sponsors and Collaborators
University Hospital of Split
University of Maryland, College Park
Investigators
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Principal Investigator: Zeljko Dujic, MD. PhD University Hospital of Split

Publications:
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Responsible Party: Zeljko Dujic, Professor Zeljko Dujic MD, PhD, University Hospital of Split
ClinicalTrials.gov Identifier: NCT02064361     History of Changes
Other Study ID Numbers: SCUBACYC
First Posted: February 17, 2014    Key Record Dates
Last Update Posted: February 17, 2014
Last Verified: February 2014
Keywords provided by Zeljko Dujic, University Hospital of Split:
SCUBA diving
exercise,
microparticles
neutrophil activation,
high intensity exercise
Additional relevant MeSH terms:
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Decompression Sickness
Barotrauma
Wounds and Injuries