Comparison of Two Periarticular Injection Medications for Adjunctive Pain Management Following Total Knee Arthroplasty (TKA)
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ClinicalTrials.gov Identifier: NCT02060591
Recruitment Status : Unknown
Verified February 2014 by Rothman Institute Orthopaedics. Recruitment status was: Recruiting
The Investigators aim to study the efficacy of Exparel as compared to Marcaine, taking into account pain control, narcotic consumption, narcotic-related side effects, outcomes measures, and patient satisfaction. Moreover, the Investigators plan to perform cost-benefit analysis to evaluate whether use of Exparel decreases analgesic consumption, duration of hospital stay and the need for physical therapy postoperatively, therefore, offsetting its higher price in comparison with Marcaine.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
All patients at least 18 years old who have primary unilateral TKA for osteoarthritis performed at Thomas Jefferson University Hospital.
American Society of Anesthesiologist (ASA) score of 4 or higher
Hepatic disease (contraindication for acetaminophen)
Renal disease (contraindication for NSAIDs)
Any contraindication for oxycodone, ketorolac, epinephrine, pregabalin, gabapentin, hydromorphone, Tramadol, morphine or other narcotics that are considered as part of routine postoperative pain control protocol
Any contraindication for intrathecal opioid injection
History of substance abuse during the last 2 years
History of allergy to amide compounds
Current consumption of monoaminoxidase (MAO) inhibitors and tricyclic antidepressant (TCA) medications
Allergy to metabisulfite compounds
Chronic use of opioid medications in the month prior to surgery (leads to opioid tolerance and/or opioid-induced hyperalgesia)
Body weight<50 Kg, BMI>40 Kg/m2
History of hypotension
Patients with any surgery related complication in the first 4-6 weeks following TKA, such as infection or mechanical failure