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Effects on Immun System of Anesthesia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02056561
Recruitment Status : Completed
First Posted : February 6, 2014
Last Update Posted : February 6, 2014
Sponsor:
Information provided by (Responsible Party):
yavuz demiraran, Duzce University

Brief Summary:

Introduction and Aim: Desflurane and sevoflurane are frequently used for maintenance of anesthesia and studies have shown that these anesthetics cause a variety of changes in oxidative stress and antioxidative defense mechanisms. The chemical structure of propofol is similar to some free radical consumers such as endogenous vitamin E and butylated hydroxene toluene. This study aims to compare the effects of sevoflurane, desflurane and propofol infusion anesthesia on the oxidant and antioxidant systems of patients undergoing laparoscopic cholecystectomy.

Material and Method: Forty-five patients, ASA (American Society of Anesthesiologists) I-II, score between 18-50 years with planned laparoscopic cholecystectomy under general anesthesia were included in the study. Patients were divided into 3 groups as total intravenous anesthesia (TIVA) (group T n: 15), sevoflurane (group S n: 15) and desflurane (group D n: 15). Propofol 2 mg/kg IV, fentanyl 1 mcg/kg IV, vecuronium 0.1 mg/kg IV given to all groups for anesthesia induction. For maintenance of anesthesia group S were ventilated with 2% sevoflurane, 50% air and 50% O2 mix at 6 L/min flow. Group D were given 6% desflurane 50% air and 50% O2 mix at 6 L/min flow. Group T were given propofol infusions of 12 mg/kg/hr for the first 10 minutes, 9 mg/kg/hr for the second 10 minutes and 6 mg/kg/hr after that. Patients were ventilated with 50% air and 50% O2 mix at 6 L/min flow. Before induction and after the operation venous blood samples were taken to evaluate the levels of glutathion peroxidase, total oxidants and antioxidants.


Condition or disease
Anesthesia

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Study Type : Observational [Patient Registry]
Actual Enrollment : 45 participants
Observational Model: Case Control
Time Perspective: Prospective
Target Follow-Up Duration: 3 Days
Official Title: Investigation Of The Effects Of General Anesthesia On The Oxidant/Antioxidant System
Study Start Date : January 2010
Actual Primary Completion Date : July 2010
Actual Study Completion Date : January 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Antioxidants

Group/Cohort
TIVA (group T n: 15)
Group T were given propofol infusions of 12 mg/kg/hr for the first 10 minutes, 9 mg/kg/hr for the second 10 minutes and 6 mg/kg/hr after that. Patients were ventilated with 50% air and 50% O2 mix at 6 L/min flow.
Sevoflurane (group S n: 15)
Group S were ventilated with 2% sevoflurane, 50% air and 50% O2 mix at 6 L/min flow.
Desflurane (group D n: 15)
Group D cases were given 6% desflurane 50% air and 50% O2 mix at 6 L/min flow.



Primary Outcome Measures :
  1. Levels of glutathion peroxidase, total oxidants and antioxidants. [ Time Frame: 24 hours ]
    Before induction and after the operation venous blood samples were taken to evaluate the levels of glutathion peroxidase, total oxidants and antioxidants.


Biospecimen Retention:   Samples With DNA
Before induction and after the operation venous blood samples were taken.


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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
45 patients ASA I-II between 18-50 years with planned laparoscopic cholecystectomy under general anesthetic were included in the study. Patients were divided into 3 groups on the way to surgery; TIVA (group T n: 15), sevoflurane (group S n: 15) and desflurane (group D n: 15).
Criteria

Inclusion Criteria:

  • ASA I-II with patients
  • Between 18-50 years
  • Planned laparoscopic cholecystectomy under general anesthetic

Exclusion Criteria:

  • Patients with endocrine dysfunction
  • blood transfusion in the previous 2 weeks
  • signs of infection and inflammation
  • history of preoperative medication use
  • anemia
  • hemorrhage requiring transfusion during the operation were excluded from the study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02056561


Locations
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Turkey
Duzce Univercity Medical Fauculty
Duzce, Turkey, 81600
Sponsors and Collaborators
Duzce University
Investigators
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Principal Investigator: yavuz demiraran, MD prof duzce university medical faculty
Additional Information:

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Responsible Party: yavuz demiraran, Professor Doctor, Duzce University
ClinicalTrials.gov Identifier: NCT02056561    
Other Study ID Numbers: MESUT-81
First Posted: February 6, 2014    Key Record Dates
Last Update Posted: February 6, 2014
Last Verified: February 2014
Keywords provided by yavuz demiraran, Duzce University:
Anesthesia
Oxidants
Antioxidants