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The Effect of Chest Compression and Ventilation Coordination During Cardiopulmonary Resuscitation.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02056509
Recruitment Status : Unknown
Verified April 2015 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : February 6, 2014
Last Update Posted : April 3, 2015
Information provided by (Responsible Party):
National Taiwan University Hospital

Brief Summary:

Airway management and maintaining adequate ventilation during cardiopulmonary resuscitation (CPR) are important. The rule of 30:2 compression-to-ventilation ratios before endotracheal intubation and keeping 1 breath every 6-8 seconds with advanced airway are generally accepted according to 2010 Advanced Cardiac Life Support (ACLS) guideline. This recommendation emphasizes on the timing and frequency of ventilation during CPR. However, poor clinical evidence had been established concerning adequate volume, airway flow and pressure in each cycle.

There are increasing evidence that hyperventilation during resuscitation reduces pulmonary venous return and, therefore, compromises cardiac output and circulation. Another research reported that using high flow oxygen mask alone during basic life support (BLS) results in better survival rate and overall outcome compared with conventional positive pressure ventilation.

Our study applies flowmeter to measure ventilation parameters as frequency, duration, exhaled volume and airway pressure on intubated patients who received artificial ventilation during CPR. The parameters will correlate with information from accelerometry and capnometry simultaneously during resuscitation. . Investigators also focus on the influence of chest compression, which increases intra-thoracic pressure considerably. This effect may act against positive pressure ventilation and probably minimize the efficiency in each ventilation or circulation..

Details about how to ventilate one patient during CPR include right timing, duration, adequate volume and coordination are in debate. Unfortunately, current practice based on clinical guidelines emphasizes little on this issue. Investigators are committed to refine contemporary practices and hopefully improve qualities of resuscitation.

Investigators proposed the hypothesis that coordinate chest compression and ventilation may minimize the increasement of airway pressure and improve the effect of circulation

Condition or disease
Out-of-Hospital Cardiac Arrest Sudden Cardiac Death

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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Effect of Chest Compression and Ventilation Coordination During Cardiopulmonary Resuscitation
Study Start Date : October 2013
Actual Primary Completion Date : February 2015
Estimated Study Completion Date : July 2015

Resource links provided by the National Library of Medicine

Out of hospital cardiac arrest
Out of hospital cardiac arrest of non-traumatic cause
Unexpected in-hospital cardiac arrest
Unexpected cardiac arrest during emergency department stay

Primary Outcome Measures :
  1. rate of 2- hour recover of spontaneous circulation [ Time Frame: 2 hours ]
    Recover of spontaneous circulation lasting for 2 hours describe as successful recover of spontaneous circulation, otherwise failure.

Secondary Outcome Measures :
  1. End tidal carbon-dioxide level [ Time Frame: Measured during and end of resuscitation ]
    End tidal carbon-dioxide level correlates with successful recovery of spontaneous circulation event

  2. Arterial blood gas data [ Time Frame: measured during and end of resuscitaiton ]
    Oxygen and carbon-dioxide tension changes in different ventilation strategy in cardiopulmonary resuscitation

  3. 30-day survival rate [ Time Frame: 30 days ]
  4. 90-day neurologic outcome [ Time Frame: 90 days ]
  5. Survive to discharge [ Time Frame: 90 days ]
    Duration of hospital stay, usually will be recorded in 90 days, occasionally will more than 90 days

  6. Timing of first shockable rhythm [ Time Frame: measured during resuscitaion ]

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Cardiac arrest patient received CPR in Emergency Department Age > 20 years old

Inclusion Criteria:

  • age > 20 years old, < 100 years old

Exclusion Criteria:

  • Trauma related out of hospital cardiac arrest

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02056509

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Contact: Hui-Chih Wang +886-2-23123456 ext 65659

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National Taiwan University Hospital Recruiting
Taipei, Taiwan, 10002
Contact: Hui-Chih Wang    +886-2-23123456 ext 65659   
Sponsors and Collaborators
National Taiwan University Hospital
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Principal Investigator: Hui-Chih Wang Emergency department, National Taiwan University Hospital
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Responsible Party: National Taiwan University Hospital Identifier: NCT02056509    
Other Study ID Numbers: 201305100RINB
First Posted: February 6, 2014    Key Record Dates
Last Update Posted: April 3, 2015
Last Verified: April 2015
Keywords provided by National Taiwan University Hospital:
cardiopulmonary resuscitation,Ventilation
Additional relevant MeSH terms:
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Out-of-Hospital Cardiac Arrest
Death, Sudden, Cardiac
Heart Arrest
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Death, Sudden