Achalasia: Mechanisms Underlying Treatment Failure
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|ClinicalTrials.gov Identifier: NCT02055469|
Recruitment Status : Unknown
Verified February 2014 by Barts & The London NHS Trust.
Recruitment status was: Not yet recruiting
First Posted : February 5, 2014
Last Update Posted : February 5, 2014
In patients with achalasia, the relationship between the perception of dysphagia, oesophageal emptying, lower oesophageal sphincter (LOS) distensibility and oesophageal circular and longitudinal muscle contraction is not clear.
We aim to characterize oesophageal circumferential and longitudinal muscle contractility and LOS distensibility in patients with achalasia (either before or after treatment). This may allow an understanding of the mechanisms underlying persistent dysphagia and delayed oesophageal emptying after treatment.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||40 participants|
|Official Title:||Achalasia; Mechanisms Underlying Persistent Symptoms After Treatment|
|Study Start Date :||March 2014|
|Estimated Primary Completion Date :||March 2015|
|Estimated Study Completion Date :||March 2015|
- Perception of dysphagia [ Time Frame: Baseline (At recruitment ) ]Questionnaires
- Oesophageal circumferential muscle contractility [ Time Frame: Baseline (At recruitment ) ]Using high resolution oesophageal manometry
- Oesophageal longitudinal muscle contraction [ Time Frame: Baseline (At recruitment ) ]High frequency intraluminal oesophageal ultrasound
- Oesophageal emptying [ Time Frame: Baseline (At recruitment ) ]Timed barium oesophagram
- Assessment of oesophageal and LOS distensibility [ Time Frame: Baseline (At recruitment ) ]Using endoscopic functional luminal imaging probe (EndoFLIP)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02055469
|Contact: Rhys Hewett, MBBSemail@example.com|
|Barts Health NHS Trust|
|London, UK, United Kingdom, E1 1BB|
|Contact: Rhys Hewett, MBBS 02035940093 ext 0093 firstname.lastname@example.org|
|Contact: Etsuro Yazaki, PhD 02035940093 ext 0093 email@example.com|
|Principal Investigator: Daniel Sifrim, MD, PhD|
|Sub-Investigator: Jafar Jafari, MBBS|
|Sub-Investigator: Etsuro Yazaki, PhD|