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TIMP-2 and IGFBP7 for the Prediction of the Cardiac Surgery Associated Acute Kidney Injury

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02054546
Recruitment Status : Completed
First Posted : February 4, 2014
Last Update Posted : February 27, 2015
Information provided by (Responsible Party):
University Hospital, Basel, Switzerland

Brief Summary:
The purpose of this study is to analyze the new biomarkers (TIMP-2 and IGFBP-7) of tubular renal cell damage for the prediction of the Cardiac Surgery Associated acute kidney injury.

Condition or disease
Acute Kidney Injury

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Study Type : Observational
Actual Enrollment : 110 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Novel Biomarkers (TIMP-2 and IGFBP7) of Tubular Renal Cell Damage for the Prediction of the Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) - A Feasibility Study
Study Start Date : December 2013
Actual Primary Completion Date : December 2014
Actual Study Completion Date : December 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Surgery

Primary Outcome Measures :
  1. AKI-stadium 1 (KDIGO) [ Time Frame: 30 days ]

Secondary Outcome Measures :
  1. all cause mortality [ Time Frame: 30 days ]

Other Outcome Measures:
  1. AKI Stadium 2-3 (KDIGO) [ Time Frame: 30 days ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
adults with planned cardiac surgery and cardiopulmonary bypass

Inclusion Criteria:

  • planned cardiac surgery

Exclusion Criteria:

  • renal dialysis
  • minors
  • emergency
  • no cardiopulmonary bypass

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02054546

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Universitätsspital Basel
Basel, Basel-Stadt, Switzerland, 4056
Sponsors and Collaborators
University Hospital, Basel, Switzerland
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Principal Investigator: Jens Fassl, MD University Hospital, Basel, Switzerland

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Responsible Party: University Hospital, Basel, Switzerland Identifier: NCT02054546    
Other Study ID Numbers: 514/13
First Posted: February 4, 2014    Key Record Dates
Last Update Posted: February 27, 2015
Last Verified: February 2015
Additional relevant MeSH terms:
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Acute Kidney Injury
Wounds and Injuries
Renal Insufficiency
Kidney Diseases
Urologic Diseases
Tissue Inhibitor of Metalloproteinase-2
Matrix Metalloproteinase Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action