Induction of Donor-Specific Tolerance in Recipients of Live Donor Stem Cell Infusion (Compassionate Use)
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Patient must be between the ages of 18 and 65 years and meet the institution's criteria for renal transplantation for end-organ failure
Patient is receiving first renal transplant
Patient is receiving a renal transplant only
The crossmatch is negative between donor and recipient
Women who are of child bearing potential must have a negative pregnancy test (urine test is acceptable) within 48 hours of initiating total body irradiation (TBI) and agree to use reliable contraception for 1 year following transplant
Potential donors who are women of child bearing potential must have a negative pregnancy test (urine test is acceptable) within 48 hours prior to receiving Granulocyte colony-stimulating factor (G-CSF)
No evidence of donor-specific antibody presently or historically
Clinically active bacterial, fungal, viral or parasitic infection
Clinical or serologic evidence of viral infection which would preclude the recipient from receiving a kidney transplant
Previous radiation therapy at a dose which would preclude TBI
Positive crossmatch between donor and recipient
Evidence for immunologic memory against donor
BMI >35 or <18
Positive serologies for hepatitis B virus (HBV), hepatitis C virus (HCV), HIV