Attentional Bias Retraining in Veterans (ABR)
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|ClinicalTrials.gov Identifier: NCT02041572|
Recruitment Status : Completed
First Posted : January 22, 2014
Last Update Posted : November 6, 2017
|Condition or disease||Intervention/treatment||Phase|
|Posttraumatic Stress Disorder||Behavioral: Attentional bias retraining||Not Applicable|
Aim 1: Develop Attentional Bias Retraining protocol (Phase 1)
- 1.1 Computerized assessment & retraining programs
- 1.2 Procedures and measures
Aim 2: Implement in pilot sample (Phase 2)
- 2.1: Assess feasibility and tolerability
- 2.2: Collect pilot data to plan future studies
- 2.3: Efficacy estimates based on changes in response time to dot probe task
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||22 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Masking Description:||The transition point from the assessment only version of the attention bias program to the retraining/ bias correction version was randomized at the participant level and occurred between weeks 4 and 7 of the 10-week study.|
|Official Title:||Attentional Bias Retraining in Veterans|
|Study Start Date :||May 2012|
|Actual Primary Completion Date :||December 2012|
|Actual Study Completion Date :||June 2015|
Attentional Bias Retraining
Each participant receives 12 sessions. The first three sessions are baseline (assessment only) sessions. The last four sessions must be treatment sessions. The attentional bias intervention starts randomly on sessions 4 - 8, and continues until the end of the 12 sessions.
Behavioral: Attentional bias retraining
Participants complete a computer-based intervention, which is designed to correct cognitive biases associated with PTSD by training to attend to neutral information rather than the trauma-related cue words.
- Post-traumatic Checklist - Military version (PCL-M) [ Time Frame: Change from Baseline and Post-treatment (1 month after last training session) ]PCL-M assess the 17-cardinal symptoms of PTSD.
- Attentional bias scores [ Time Frame: Change from Baseline and Post-treatment (1 month after last training session) ]Attentional bias scores represent participants cognitive bias to orient towards trauma-relevant information more quickly than neutral information.
- Daily of PTSD symptoms, specifically hyperarousal and intrusive symptoms (nightmares, reenactments, and triggered and untriggered recall) [ Time Frame: Change from Baseline and Post-treatment (1 month after last training session) ]Participants filled out daily symptom log nightly
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02041572
|United States, Hawaii|
|National Center for PTSD|
|Honolulu, Hawaii, United States, 96819|
|Principal Investigator:||Margaret-Anne Mackintosh, PhD||National Center for PTSD/PHREI|