High Resolution Magnetic Resonance Imaging in Patients With Brain Tumors
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
The study will compare two different size MRI's of a brain tumor.
Condition or disease
The study is designed to directly compare the MR images of a brain tumor obtained on the 3T and then 7T MRI in approximately 150 patients followed serially with MR imaging to evaluate for tumor progression.
Benefit of 7T MR imaging [ Time Frame: Baseline and 6 month intervals after baseline ]
1. To determine the benefit of 7T MR imaging in brain tumor patients with regard to the improvement in resolution, as measured by the area of T2 FLAIR signal abnormality and the ability to detect abnormalities in vascular integrity. The benefit will be determined at a single time point as well as longitudinally for each patient at 6 month intervals.
Secondary Outcome Measures :
Vascular Integrity [ Time Frame: Every 6 months, up to 12 months. ]
To determine if changes in vascular integrity at 7T can be correlated with tumor progression or transformation to high grade in patients with low grade gliomas.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients at the Simmons Cancer Center at UTSW
Male or female, age 18 years or older
Patient must meet at least one of the four following criteria regarding brain tumor diagnosis:
Histological diagnosis of a brain tumor
Histological diagnosis of systemic cancer and brain MR imaging suggestive of metastatic disease to the brain
Pre-operative brain MR imaging suggestive of a brain tumor
Radiographic diagnosis of brain tumor in an inoperable location (e.g., brainstem)
Patient able and willing to provide informed consent
Karnofsky Performance status > 70%
Life expectancy greater than 3 months
Negative serum or urine pregnancy test or child bearing potential terminated by surgery, radiation, menopause or current use of two approved methods of birth control
Patients who are excluded from 7T MR imaging because of titanium implants that are not yet established to be safe at 7T remain eligible for the imaging at 3T * Spanish speaking participants will be enrolled for this study
Body weight >137 Kg (300 lbs)
Patient unable to provide informed consent
Karnofsky Performance status < 70%
Patients who are claustrophobic or have other contraindications to MRI, such as implanted pacemaker device vascular clips, surgical clips, prosthetic valves, pacemakers, otologic implants
NYHA class III and IV congestive heart failure
Psychiatric or addictive disorders that preclude obtaining informed consent
Sexually active patients of childbearing potential not using a reliable contraceptive method
Pregnant or lactating women
Women of childbearing potential who refuse a pregnancy test (performed during screening)