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Adductor Canal Versus Femoral Nerve Block for Analgesia Post Total Knee Arthroscopy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02033603
Recruitment Status : Unknown
Verified January 2014 by Changi General Hospital.
Recruitment status was:  Recruiting
First Posted : January 13, 2014
Last Update Posted : January 1, 2015
Information provided by (Responsible Party):
Changi General Hospital

Brief Summary:

Total knee arthroplasty or replacement (TKA) is a surgery performed for osteoarthritis of the knee which is increasingly performed as the population ages. It is a painful surgery and one of the methods to reduce post-operative pain is performing a regional anaesthesia technique. The current practice is to perform a femoral nerve block (FNB) which blocks the nerves supplying the knee joint and the thigh muscles (quadriceps). This provides effective analgesia. However, it also results in weakness of the quadriceps and may result in falls post-operatively.

Adductor canal block (ACB) is a new, alternative regional anaesthesia technique which is hypothesised to provide as effective analgesia, with less quadriceps weakness compared to FNB, hence potentially reducing the risk of falls post-operatively.

Investigators aim to study if the analgesia provided by ACB is as good as FNB while preserving quadriceps strength.

Condition or disease Intervention/treatment Phase
Knee Osteoarthritis Drug: Ropivacaine Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Femoral Nerve Block for Analgesia Post Total Knee Arthroplasty
Study Start Date : January 2014
Actual Primary Completion Date : September 2014
Estimated Study Completion Date : December 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Osteoarthritis

Arm Intervention/treatment
Active Comparator: Femoral Nerve Block
Femoral Nerve block performed with 0.5% Ropivacaine 30mls (150mg)
Drug: Ropivacaine
30mls of 0.5% ropivacaine
Other Name: naropin

Active Comparator: Adductor Canal block
Adductor Canal block performed with 0.5% Ropivacaine 30mls (150mg)
Drug: Ropivacaine
30mls of 0.5% ropivacaine
Other Name: naropin

Primary Outcome Measures :
  1. Morphine consumption [ Time Frame: first 24 hours ]

Secondary Outcome Measures :
  1. Pain scores [ Time Frame: 1, 6, 12, 24, 48 ]
  2. Morphine consumption [ Time Frame: 48 hours ]
  3. Side effects of opioids- sedation, nausea and vomiting [ Time Frame: 48 hours ]
  4. Quadriceps strength, ability to mobilise [ Time Frame: 24, 48 hours ]

Information from the National Library of Medicine

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Ages Eligible for Study:   45 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • ages 45-85
  • American Society of Anaesthesiologists physical status 1-3
  • BMI 18-35 kg/m2

Exclusion Criteria:

  • inability to give consent, communicate, cooperate
  • Patients with regular consumption of strong opioids (morphine, oxycodone) or steroids
  • Patients with allergy to local anaesthetics or any drugs included in the study
  • Patients with lower limb surgery in the preceding year
  • Patients with pre-existing neurological deficits
  • Patients who are unsuitable for general anaesthetics (eg difficult airway)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02033603

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Contact: CTRU CGH 67888833

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Changi General Hospital Recruiting
Singapore, Singapore, 529889
Contact: CTRU    67888833      
Sponsors and Collaborators
Changi General Hospital
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Principal Investigator: Yean Chin Lim, MBBS, MMed Changi General Hospital

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Responsible Party: Changi General Hospital Identifier: NCT02033603     History of Changes
Other Study ID Numbers: 2013/ 921/ D
First Posted: January 13, 2014    Key Record Dates
Last Update Posted: January 1, 2015
Last Verified: January 2014
Keywords provided by Changi General Hospital:
Total knee arthroplasty
Total knee replacement
Femoral Nerve Block
Adductor Canal Block
Additional relevant MeSH terms:
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Osteoarthritis, Knee
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Anesthetics, Local
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents