Newborn Feeding and Infant Phenotype
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|ClinicalTrials.gov Identifier: NCT02033005|
Recruitment Status : Completed
First Posted : January 10, 2014
Results First Posted : June 7, 2019
Last Update Posted : June 7, 2019
Breast feeding is believed to be beneficial to long-term health but how these effects are mediated is unknown. I suggest that this may be through effects on body composition and metabolism.
I will compare adipose tissue and liver fat deposition in healthy, full term breast and formula fed infants babies shortly after birth and around 12 weeks.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||124 participants|
|Official Title:||Newborn Feeding and Infant Phenotype|
|Study Start Date :||March 2010|
|Actual Primary Completion Date :||July 2012|
|Actual Study Completion Date :||July 2012|
>80% of feeds consisting of breast milk at both scanning points
>80% of feeds consisting of formula milk at both scanning points
20%-80% of feeds consisting of breast milk.
- Change in Total Adipose Tissue Volume [ Time Frame: Between birth and 6-12 weeks age ]Difference in total adipose tissue volume, measured using whole body magnetic resonance imaging.
- Change in Regional Adipose Tissue Distribution Compared to Breastfed Infants. [ Time Frame: Between birth and 6-12 weeks age ]Change in regional adipose tissue distribution (ratio of internal abdominal to total subcutaneous abdominal adipose tissue) measured using whole body magnetic resonance imaging
- Change in Intrahepatocellular Lipid Compared to Breastfed Infants. [ Time Frame: Between birth and 6-12 weeks age ]Change in intrahepatocellular lipid (IHCL) compared to breastfed infants, measured using in-vivo hepatic magnetic resonance spectroscopy
Biospecimen Retention: Samples Without DNA
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02033005
|Chelsea and Westminster Hospital NHS Foundation Trust|
|London, United Kingdom, SW10 9NH|
|Principal Investigator:||Neena Modi, MBBS, MD||Imperial College London|