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Trial record 89 of 668 for:    CARBON DIOXIDE AND arterial

The Feasibility of PetCO2 Prediction Hypotension Under Spinal Anesthesia for Cesarean Section

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ClinicalTrials.gov Identifier: NCT02032355
Recruitment Status : Unknown
Verified January 2014 by Geng guiqi, Fudan University.
Recruitment status was:  Recruiting
First Posted : January 10, 2014
Last Update Posted : January 10, 2014
Sponsor:
Information provided by (Responsible Party):
Geng guiqi, Fudan University

Brief Summary:

Maternal hypotension is a common side effect after spinal anesthesia for cesarean delivery.Decreased vascular resistance and cardiac output, due to sympathetic blockade1and blood pooling in blocked areas of the body respectively, are main causes of spinal anaesthesia-induced hypotension during Caesarean delivery.

Cardiac output, which has shown to be a better predictor of organ and placental perfusion than arterial blood pressure.Few studies have measured CO after spinal anesthesia in the maternal population.This is largely because of the lack of availability of accurate and reproducible noninvasive measurement techniques. Up to now, preventing hypotension has continued to focus on arterial blood pressure variables, fluid, and ephedrine requirements as markers of cardiovascular status, because these are more easily measured.

Investgators hypothesized that CO and PetCO2, in parturients with the degree of hypotension during spinal anaesthesia, would also have a positive and significant association.


Condition or disease Intervention/treatment
Hypotension Carbon Dioxide Procedure: spinal anesthesia

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Study Type : Observational
Estimated Enrollment : 6 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: The Feasibility of PetCO2 Prediction Hypotension Under Spinal Anesthesia for Cesarean Section
Study Start Date : January 2014
Estimated Primary Completion Date : February 2014
Estimated Study Completion Date : February 2014

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
hypotension Procedure: spinal anesthesia



Primary Outcome Measures :
  1. value of PetCO2 and changes in artery pressure [ Time Frame: up to 4 weeks ]


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
American Society of Anesthesiologists physical status I and II patients undergoing elective cesarean delivery under combined spinal-epidural (CSE) anesthesia
Criteria

Inclusion Criteria:

  • full-term gestation (>36 and <41 weeks of gestation) with a singleton pregnancy

Exclusion Criteria:

  • emergency cases
  • placenta praevia
  • preeclampsia
  • cardiovascular or cerebrovascular disease
  • morbid obesity with a BMI≥40
  • contraindications to spinal anaesthesia

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02032355


Locations
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China, Shanghai
Obstetrics & Gynecology Hospital, Fudan University Recruiting
Shanghai, Shanghai, China, 200090
Contact: congjian xu, PhD    86 2163455050    xucj@hotmail.com   
Sponsors and Collaborators
Geng guiqi

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Responsible Party: Geng guiqi, professor, Fudan University
ClinicalTrials.gov Identifier: NCT02032355     History of Changes
Other Study ID Numbers: 61538
First Posted: January 10, 2014    Key Record Dates
Last Update Posted: January 10, 2014
Last Verified: January 2014
Additional relevant MeSH terms:
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Hypotension
Vascular Diseases
Cardiovascular Diseases
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs