The Role of TLR-4 Polymorphisms in Children With Urinary Track Infections (TLR-4)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02021305|
Recruitment Status : Unknown
Verified December 2013 by Panagiota Karananou, Aristotle University Of Thessaloniki.
Recruitment status was: Recruiting
First Posted : December 27, 2013
Last Update Posted : December 27, 2013
Purpose So far anatomical abnormalities (mostly congenital) were, in the majority of the patients, associated with urinary track infections. In this study the researchers will try to investigate the role of TLRs as molecular interactions between bacterial virulence and host response.
TLRs are important mediators in the development of the natural immunity against bacteria. They recognize microbial pathogen associated molecular patterns and alert the host's immune system to the presence of invading microbes
|Condition or disease|
|Urinary Tract Infection|
The aim of his observational case-control study is to :
- investigate if the expression of TLR2 and TLR4 mediate in the development of the natural immunity of the uroepithileal cells against bacteria.
- evaluate the effect of the TLR-gene Asp299Gly and Thr399Ile polymorphisms on the development and clinical severity of urinary tract infections (UTI) in children.
- determine the association of the expression of TLR-2 and TLR-4 and TLR-4 polymorphisms with the formation of renal scar in children.
- investigate the expression of TLR-2 and TLR-4 and TLR-4 polymorphisms in healthy children and elaborate the results to the possible carriers of these polymorphisms.
|Study Type :||Observational|
|Estimated Enrollment :||160 participants|
|Official Title:||The Role of TLR-4 Asp299Gly and Thr399Ile Polymorphisms in Children With Urinary Tack Infections|
|Study Start Date :||February 2013|
|Estimated Primary Completion Date :||February 2014|
|Estimated Study Completion Date :||February 2017|
60 children with a recorded episode of acute Urinary Track infection who attended 4th Department of Pediatrics of Medical School of Aristotle University of Thessaloniki.
100 children with no history of Urinary Track Infection who attended 4th Department of Pediatrics of Medical School of Aristotle University of Thessaloniki.
- frequency of TLR-4 299, 399 polymorphism and expression of TLR-2 and TLR-4 by monocytes in children with urinary track infection and healthy controls. [ Time Frame: 4 years ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02021305
|Contact: Efimia Papadopoulou-Alataki, MD, PhD||+302313323901 ext firstname.lastname@example.org|
|Contact: Panagiota Karananou, MD||+302313323901 ext email@example.com|
|Study Director:||Efimia Papadopoulou-Alataki, MD, PhD||Aristotle University Of Thessaloniki|