Monoamine Contributions to Neurocircuitry in Eating Disorders
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|ClinicalTrials.gov Identifier: NCT02020408|
Recruitment Status : Completed
First Posted : December 24, 2013
Results First Posted : April 27, 2020
Last Update Posted : April 27, 2020
|Condition or disease||Intervention/treatment||Phase|
|Eating Disorder||Drug: [11C]raclopride Drug: [11C]DASB Drug: amphetamine||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||88 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Monoamine Contributions to Neurocircuitry in Eating Disorders|
|Study Start Date :||May 2011|
|Actual Primary Completion Date :||December 31, 2017|
|Actual Study Completion Date :||December 31, 2017|
Experimental: [11C]raclopride, [11C]DASB, amphetamine
One time administration of oral amphetamine based on subject's weight (0.5 mg/kg). One PET scan using [11C]DASB. Two PET scans using [11C]raclopride.
1.[11C]raclopride -The change (Δ) in BPND (the difference between the [11C]raclopride BPND at baseline and post-AMPH treatment normalized to the baseline BPND
Other Name: Raclopride, serial number 009
BPND of [11C]DASB.
Other Name: DASB, serial number 0011
The change (Δ) in BPND (the difference between the [11C]raclopride BPND at baseline and post-AMPH treatment normalized to the baseline BPND.
Other Name: dextroamphetamine
- 5-HT Transporter Binding as Measured During the PET Scan [ Time Frame: 90 minute PET scan ]
Use PET and [11C]DASB to explore 5-HTT receptor binding potential midbrain and striatal regions of interest in eating disorder subtypes.
The Binding Potential (BP) was calculated as BP Non Displaceable (ND) = (VT/VND) -1. [VT = distribution volume in tissue; VND = non-displaceable distribution volume]. The binding of the 5-HTT on PET presumably reflects 5-HTT density and/or affinity.
- Dopamine D2/D3 Receptor Binding as Measured During the PET Scan After Amphetamine Administration [ Time Frame: 90 min PET scan ]Use PET and [11C]raclopride to explore Dopamine D2/D3 receptor binding potential (BPND) in striatal regions of interest in eating disorder subtypes after amphetamine administration. The Binding Potential (BP) was calculated as BP Non Displaceable (ND) = (VT/VND) -1. [VT = distribution volume in tissue; VND = non-displaceable distribution volume].
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02020408
|United States, California|
|University of California San Diego|
|San Diego, California, United States, 92102|
|Principal Investigator:||Walter Kaye, MD||UCSD|
|Principal Investigator:||Ursula Bailer, MD||UCSD|