Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis
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ClinicalTrials.gov Identifier: NCT02010307 |
Recruitment Status : Unknown
Verified December 2013 by Polak David, Hadassah Medical Organization.
Recruitment status was: Not yet recruiting
First Posted : December 12, 2013
Last Update Posted : December 16, 2013
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aggressive periodontitis is an inflammatory disease which damage the teeth supporting structures mostly in young patients. and has genetic basis.
a specific bacteria: Aggregatibacter actinomycetemcomitans (Aa) is associated with this disease, and found to damage leukocytes by using a specific leukotoxin.
in the research the investigators are aiming to find molecular and immunological basis to aggressive periodontitis.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Periodontal Disease | Other: blood extraction | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 75 participants |
Allocation: | Non-Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Study Start Date : | January 2014 |
Estimated Primary Completion Date : | January 2015 |
Estimated Study Completion Date : | October 2015 |
Arm | Intervention/treatment |
---|---|
Experimental: aggressive periodontitis
25 patients with aggressive periodontitis blood extraction
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Other: blood extraction
6 ml blood extraction from each patients in all 3 arms of the study |
Experimental: chronic periodontitis
25 patients with chronic periodontitis blood extraction
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Other: blood extraction
6 ml blood extraction from each patients in all 3 arms of the study |
Experimental: healthy
25 healthy periodontal patients blood extraction
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Other: blood extraction
6 ml blood extraction from each patients in all 3 arms of the study |
- flow cytometry [ Time Frame: 12 hours after blood extraction ]the investigators use flow cytometry technique in order to determine the influence of gingival bacteria on the leukocytes, after culturing the two together.
- microscopy observation [ Time Frame: 12 hours after blood extraction ]the investigators use microscopy in order to determine the influence of gingival bacteria on the leukocytes, after culturing the two together

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Ages Eligible for Study: | 18 Years to 50 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- patients in periodontal department
- healthy
- diagnosed with chronic/aggressive periodontal disease
- interested in participating the research
Exclusion Criteria:
- diagnosed with diabetes, heart disease, immunosuppression, thrombocytopenia, clotting enzyme deficiency.
- using alcohol, or drugs
- pregnancy

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02010307
Contact: David Polak, DMD, PhD | 00972- 52-593-3961 | polak@mail.huji.ac.il | |
Contact: Hadas Lemberg, PhD | 00-972-2-6777572 | lhadas@hadassah.org.il |
Israel | |
Hadassah Medical Organization, Jerusalem, Israel | |
Jerusalem, Israel |
Principal Investigator: | David Polak, DMD, PhD | Haddasah Medical Center |
Responsible Party: | Polak David, senior dentist, periodontology department, Hadassah Medical Organization |
ClinicalTrials.gov Identifier: | NCT02010307 |
Other Study ID Numbers: |
davidp-HMO-CTIL |
First Posted: | December 12, 2013 Key Record Dates |
Last Update Posted: | December 16, 2013 |
Last Verified: | December 2013 |
Periodontal Diseases Mouth Diseases Stomatognathic Diseases |