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Bioavailability of Anthocyanins of Blue Potatoes as Compared With Bilberries

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ClinicalTrials.gov Identifier: NCT02005796
Recruitment Status : Completed
First Posted : December 9, 2013
Last Update Posted : May 20, 2015
Sponsor:
Information provided by (Responsible Party):
Kaisa Linderborg, University of Turku

Brief Summary:
In this study, the postprandial glycemia and insulinemia caused by boiled potato with blue-fleshed or yellow-fleshed tubers, or a gel prepared with bilberries and potato starch, is studied in healthy males. Additionally, the appearance and metabolism of the flavonoids and their metabolites is studied in plasma and urine.

Condition or disease Intervention/treatment Phase
Postprandial Glycemia Other: Dietary intervention Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 14 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: Bioavailability of Anthocyanins of Blue Potatoes as Compared With Bilberries
Study Start Date : December 2013
Actual Primary Completion Date : May 2015
Actual Study Completion Date : May 2015

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Blue-fleshed potato tubers
Intervention: Steam cooked mashed potato tubers
Other: Dietary intervention
Experimental: Yellow-fleshed potato tubers
Intervention: Steam cooked mashed potato tubers
Other: Dietary intervention
Experimental: Bilberries and potato starch
Intervention: A gel boiled with bilberries and potato starch
Other: Dietary intervention



Primary Outcome Measures :
  1. Plasma glucose concentration [ Time Frame: 20min, 40min, 60min, 90min, 120min, 180min, 240min ]
  2. Plasma insulin concentration [ Time Frame: 20min, 40min, 60min, 90min, 120min, 180min, 240min ]

Secondary Outcome Measures :
  1. Concentrations and quality of flavonoid color compounds or their metabolites in plasma and urine (HPLC-measurement) [ Time Frame: 20min, 40min, 60min, 90min, 120min, 180min, 240min ]
  2. Concentrations and quality of flavonoid color compounds or their metabolites in plasma and urine (NMR-measurement) [ Time Frame: 20min, 40min, 60min, 90min, 120min, 180min, 240min ]


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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age 18-45
  • Male
  • No regular medication
  • No participation in a drug trial or blood donation within 2 months
  • Non-smoker
  • Signs informed consent
  • Body mass index 18.5-27 kg/m2
  • Fasting plasma cholesterol < 5.5 mmol/l
  • Fasting plasma triacylglycerols < 2.6 mmol/l
  • Fasting plasma glucose 4-6 mmol/l
  • blood pressure <140/80 mmHg
  • hemoglobin>130 g/l
  • Fasting plasma alanine amino transferase (ALAT) <60 U/l (normal liver function)
  • Fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function)
  • Fasting plasma creatinine <118 µmol/l (normal kidney function)

Exclusion Criteria:

  • Regular smoking
  • Alcohol abuse
  • Regular medication

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02005796


Locations
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Finland
Department of Biochemistry, University of Turku
University of Turku, Turku, Finland, 20014
Sponsors and Collaborators
University of Turku

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Responsible Party: Kaisa Linderborg, PhD, University of Turku
ClinicalTrials.gov Identifier: NCT02005796     History of Changes
Other Study ID Numbers: Siniset perunat
First Posted: December 9, 2013    Key Record Dates
Last Update Posted: May 20, 2015
Last Verified: May 2015