Randomized Trial of Outpatient vs. Inpatient Management of Low-risk Patients With Upper Gastrointestinal Bleeding.
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ClinicalTrials.gov Identifier: NCT02005705
Recruitment Status :
Patients presenting to the emergency room with upper gastrointestinal bleeding and a Glasgow Blatchford score of zero will be randomly assigned to further care in the inpatient vs. outpatient setting. The hypothesis of this study is that patients who are managed as outpatients will require interventions at a rate not higher than those managed as inpatients and will have lower direct healthcare costs.
Condition or disease
Upper Gastrointestinal Bleeding
Other: Outpatient Management of Low-risk PatientsOther: Inpatient Management of Low-risk Patients
The number of patients requiring intervention for UGIB (endoscopic therapy, blood transfusion, surgery, interventional radiology) [ Time Frame: Within 7 days of the index presentation to the emergency room ]
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Blood Urea Nitrogen < 18.2 mg/dl
Hemoglobin ≥ 13.0 g/dl for men and ≥ 12.0 g/dl for women
Systolic blood pressure ≥ 110 mm Hg
Heart rate < 100 beats/min
Inability to obtain informed consent
History of liver disease
History of heart failure
Syncope that is temporally related to ongoing bleeding
Contraindication to proton pump inhibitor use
Other conditions that necessitate inpatient evaluation.