In France the prevalence of pre-lingual deafness is between 1 and 1.4 per 1000 habitants, and according to very conservative estimates, about 44 000 deaf persons use the sign language. Additionally, the prevalence of dementia in France is close to 1% (850 000 dements for a total population of 65 millions). The prevalence of dementia in pre-lingual deaf adults has also been described and is between 1 and 1.4 /100 000 habitants.
The Mini Mental State Examination (MMSE) of Folstein is a test recommended to perform the cognitive evaluation for the detection of mental disorders including dementia, and a consensual French version exists prepared by GRECO (Group of Research and Cognitive Assessments). However, to date, there are no simple, rapid and validated screening tests to study cognitive disorders in deaf persons who use the sign language. The only tests available allow a late diagnosis avoiding an optimal treatment of the patients.
Primary Outcome Measures:
- Assessment of internal consistency of MMS-LS test for the diagnosis of cognitive impairment among deaf patients by a correlation analysis followed by Cronbach's alpha test [ Time Frame: At baseline, 1 year and 2 years follow-up visits ]
Secondary Outcome Measures:
- Description of MMS-LS test results [ Time Frame: Baseline ]
Explanatory Factors are: age, education level, characteristics of the sign language(fluency level, learning age, usage frequency, usage by other family members)
- Diagnostic performance and predictive values of MMS-LS test for acquired dementia. [ Time Frame: Baseline, 1 year and 2 years follow-up visits ]
Sensitivity, specificity, positive and negative predictive values.
- Correlation between MMS-LS score and CDR level [ Time Frame: Baseline, 1 year and 2 years follow-up visits ]
We also check that patients having a suspicious CDR (0.5) have a superior MMS-LS score compared to patients having a CDR ≥ 1.
- Diagnostic performance and predictive values of MMS-LS test for suspected dementia. [ Time Frame: Baseline, 1 year and 2 years follow-up visits ]
Sensitivity, specificity, positive and negative predictive values
| Estimated Enrollment:
| Study Start Date:
| Estimated Study Completion Date:
| Estimated Primary Completion Date:
||October 2017 (Final data collection date for primary outcome measure)
Experimental: deaf persons with potential dementia
Behavioral: application of the mini-mental state test
The objective of this study is to assess the intrinsic quality of the tool MMS-LS, a mini-mental state examination that has been adapted to the sign language in order to monitor cognitive disorders in deaf people who speak sign language.