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Trial record 73 of 1009 for:    Area Under Curve AND insulin

Effect of Low-carbohydrate/High-fat Diet on Glucose Tolerance and Lipid Profile in Lean, Healthy Women (LCHF)

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ClinicalTrials.gov Identifier: NCT02005224
Recruitment Status : Completed
First Posted : December 9, 2013
Last Update Posted : December 9, 2013
Sponsor:
Collaborator:
Norwegian School of Sport Sciences
Information provided by (Responsible Party):
Atlantis Medical University College

Brief Summary:
Intervention studying the effect of a low-carbohydrate/high-fat (LCHF) diet as well as on bout of exercise in combination with either a normal diet or a LCHF diet, in relation to glucose metabolism, insulin sensitivity, lipid profile and body composition.

Condition or disease Intervention/treatment Phase
Insulin Sensitivity Weight Other: LCHF diet and a bout of exercise Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 17 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Effect of Low-carbohydrate/High-fat Diet on Glucose Tolerance and Lipid Profile in Lean, Healthy Women
Study Start Date : August 2012
Actual Primary Completion Date : November 2012
Actual Study Completion Date : March 2013

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
LCHF diet and a bout of exercise
LCHF diet for 3 weeks, where E% 70 fat, E% 20-25 proteins and 20g or less carbohydrates. Oral glucose tolerance test on the morning of day 21 followed by a bout of exercise in the afternoon (indoor bicycle, 60min at 75% HFpeak). The following morning (day 22) a new oral glucose tolerance test. Oral glucose tolerance test results from pre-tests used to determine the effect of LCHF and a bout of exercise on insulin sensitivity.
Other: LCHF diet and a bout of exercise
Low-carbohydrate/high-fat diet; effect on insulin sensitivity, lipid profile, weight and body composition. Participants ingested LCHF diet for three weeks before undergoing an oral glucose tolerance test. The same afternoon the participated in an one hour indoor bicycle training at 75% at HFpeak. The following morning they underwent a new oral glucose tolerance test. Body composition and weight were measured before and after the intervention. Oral glucose tolerance test was also performed before the intervention for baseline. Blood samples were collected before and after the intervention for lipid profile analyses.




Primary Outcome Measures :
  1. Area under the curve glucose (0, 15, 30, 45, 60, 90 and 120 min) [ Time Frame: -1 week, 3 weeks ]
    performed by oral glucose tolerance test, 75 g glucose, 300 ml water



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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Females
  • Normal weight
  • BMI between 18.5 and 25
  • Moderately trained

Exclusion Criteria:

  • Smokers/tobacco users
  • pregnancy
  • familial cardio-vascular-disease
  • diabetes or reduced glucose tolerance
  • under- or overweight (BMI under 18.5 or over 25)
  • top athletes

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02005224


Locations
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Norway
Norwegian School of Sport Sciences
Oslo, Norway, 0806
Sponsors and Collaborators
Atlantis Medical University College
Norwegian School of Sport Sciences
Investigators
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Study Director: Jorgen Jensen, PhD Norwegian School of Sport Sciences - Department of Physical Performance

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Responsible Party: Atlantis Medical University College
ClinicalTrials.gov Identifier: NCT02005224     History of Changes
Other Study ID Numbers: AMUC-NIH-LCHF-P1-2012
First Posted: December 9, 2013    Key Record Dates
Last Update Posted: December 9, 2013
Last Verified: December 2013

Keywords provided by Atlantis Medical University College:
Insulin sensitivity
Lipid profile
Body composition
Weight

Additional relevant MeSH terms:
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Hypersensitivity
Insulin Resistance
Immune System Diseases
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases
Insulin
Hypoglycemic Agents
Physiological Effects of Drugs