Effect of Desflurane on Cardiac Function During Cardiac Surgery: Tissue Doppler Imaging of Mitral Valve Annular Velocity
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|ClinicalTrials.gov Identifier: NCT02003885|
Recruitment Status : Unknown
Verified March 2015 by Tae-Yop Kim, MD PhD, Konkuk University Medical Center.
Recruitment status was: Recruiting
First Posted : December 6, 2013
Last Update Posted : March 6, 2015
|Condition or disease||Intervention/treatment||Phase|
|Valvular Heart Disease||Drug: increment of desflurane||Not Applicable|
Tissue Doppler imaging (TDI ) of mitral annular velocity during the cardiac cycle has been introduced as a reliable method for analysis of systolic and diastolic LV ling-axix function , efficacy of diastolic TDI profile, including early early relaxation (E') and atrial contraction (A') and has been suggested to be useful in predicting the postoperative clinical outcomes and the impact of isoflurane on LV diastolic function.
Desflurane is widely used in cardiac surgery patients due to its beneficial effects , but many studies have shown that desflurane reduces myocardial contractility in a dose-dependent manner, and compromises left ventricular( LV) function We hypothesized that desflurane , even at a clinical dosage, would affects intraoperative LV systolic function in a dose-dependent manner and thus produce significant changes int the TDI profiles of mitral annular velocity.
So we planned to study the changes in TDI profiles of lateral mitral annular velocity at the clinical desflurane dosage during remifentanil based anesthesia for cardiac surgery
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||14 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effect of Desflurane on Left Ventricular Function in Remifentanil-based Anesthesia for Cardiac Surgery: Tissue Doppler Imaging of Mitral Valve Annular Velocity|
|Study Start Date :||January 2014|
|Estimated Primary Completion Date :||August 2015|
|Estimated Study Completion Date :||September 2015|
Experimental: Desflurane increment
increment of desflurane 0.5-1.5 MAC in remifentanil anesthesia for cardiac surgery
Drug: increment of desflurane
After achieving stable hemodynamics and BIS 40-60 with desflurnae 0.5 MAC and remifentanil 0.7-1.0 mcg/kg/min (T1), data including S', E', A', EF, E, A and BIS are determined.
After 10 min exposure to the increased desflurane dosage 1.0 MAC (T2), data are determiend. After 10 min exposure to the increased desflurane dosage 1.5 MAC (T3), data are determined.
Reduction of BP is managed by the increment of phenylephrine infusion
Other Name: Desflurane inhalation 0.5 MAC, 1.0 MAC and 1.5 MAC
- Peak systolic mitral annular velocity (S') [ Time Frame: after 10 min exposure to desflurane 0.5, 1.0 and 1.5 MAC ]Peak systolic mitral annular velocity (S') using tissue Doppler imaging By using pulsed Doppler with the sample volume positioned at the lateral mitral valve (MV)ring in the midesophageal 4-chamber view, S' would be determined just after the 10 min-exposure to each concentration of desflurane, 0.5 MAC, 1.0 MAC and 1.5 MAC (T1, T2 and T3, respectively)
- diastolic mital annular veocities (E' and A'), ejection fraction (EF), Bispectral index [ Time Frame: after 10 min exposure to desflurane 0.5, 1.0 and1.5 MAC ]Peak mitral annular velocity during early diastole (E'): By using pulsed Doppler with the sample volume positioned at the lateral MV ring in the midesophageal 4-chamber view, Peak mitral annular velocity during atrial contraction(A'): By using pulsed Doppler with the sample volume positioned at the lateral MV ring in the midesophageal 4-chamber view, ejection fraction (EF): By using modified Simpson technique in the midesophageal 4-chamber view, bispectral index (BIS) peak velocity of mitral inflow during early relaxation (E): By using pulsed Doppler with the sample volume positioned at the IMV opening in the midesophageal 4-chamber view, peak velocity of mitral inflow during atrial contraction (A): By using pulsed Doppler with the sample volume positioned at the tip of MV opening in the midesophageal 4-chamber view,
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02003885
|Contact: Tae-Yop Kim, MD, PhD||82-10-8811-6942|
|Korea, Republic of|
|Konkuk University Medical Center||Recruiting|
|Seoul, Korea, Republic of, 143729|
|Contact: Seong-Ho Lee 82-2-2030-6522 firstname.lastname@example.org|
|Principal Investigator:||Tae-Yop Kim, MD, PhD||Konkuk University Medical Center|