The Effect of Pnemoperitoneum on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Surgery According to Anesthesia Agents: Propofol Based Total Intravenous Anesthesia vs Desflurane Anesthesia
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|ClinicalTrials.gov Identifier: NCT02003768|
Recruitment Status : Withdrawn
First Posted : December 6, 2013
Last Update Posted : July 15, 2014
Information provided by (Responsible Party):
The pneumoperitoneum during laparoscopic surgery have the potential to cause an increase of intracranial pressure (ICP). Previous studies have proposed that ultrasonographic measurements of the optic nerve sheath diameter (ONSD) correlate with signs of increased ICP. The aim of this study is to compare the effect of pnemoperitoneum on intracranial pressure and cerebral oxygenation during laparoscopic surgery according to anesthesia agents, propofol based total intravenous anesthesia (TIVA group) and desflurane anesthesia (Des group).
|Condition or disease||Intervention/treatment||Phase|
|Optic Nerve Sheath||Drug: Propofol Drug: Desflurane||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Intervention Model:||Parallel Assignment|
|Study Start Date :||October 2013|
|Estimated Primary Completion Date :||June 2015|
|Estimated Study Completion Date :||October 2015|
2% Propofol (Fresofol®), Remifentanil 20mcg/cc (Ultiva®)
80 patients are randomly allocated into two groups: In TIVA group, propofol based total intravenous anesthesia is used to induce and maintain anesthesia for laparoscopic cholescystectomy.
Active Comparator: Des
Desflurane (Suprane®), Remifentanil continuous infusion (20mcg/cc)
80 patients are randomly allocated into two groups : In Des group, inhalation anesthesia using desflurane is used to induce and maintain anesthesia for laparoscopic cholescystectomy.
Primary Outcome Measures :
- the ultrasonographic measurement of optic nerve sheath diameter [ Time Frame: baseline ]optic nerve sheath diameter measured by ultrasonography
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