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Prevalence and Outcome of Hypermetabolism in Initial Prevalence and Outcome of Hypermetabolism in Initial Phase of Intensive Care Unit Patient: a Prospective Observational Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02002676
Recruitment Status : Unknown
Verified June 2014 by Chao Wu, Nanjing University School of Medicine.
Recruitment status was:  Recruiting
First Posted : December 6, 2013
Last Update Posted : June 13, 2014
Sponsor:
Collaborator:
Jinling Hospital, China
Information provided by (Responsible Party):
Chao Wu, Nanjing University School of Medicine

Brief Summary:
Patients in critical illness frequently present hypermetabolism, which can extremely increase the rest energy expenditure(REE). We hypothesize that if we alleviate the extremely increased REE will improve ICU patients' outcome

Condition or disease
SIRS Sepsis Septic Shock

Detailed Description:
This study focuses on the early changes of REE of critical ill patients when they admitted to ICU.

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Study Type : Observational
Estimated Enrollment : 62 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Prevalence and Outcome of Hypermetabolism in Initial Phase of Intensive Care Unit Patient: a Prospective Observational Study
Study Start Date : December 2013
Estimated Primary Completion Date : June 2014
Estimated Study Completion Date : June 2014



Primary Outcome Measures :
  1. Mortality rate of 28 days [ Time Frame: From ICU admission to 28th days of observation ]

Secondary Outcome Measures :
  1. Incidence of Multiple Organ Dysfunction Syndrome(MODS)in 60 days [ Time Frame: From ICU admission to 60th days of observation ]

Other Outcome Measures:
  1. Length of stay in ICU [ Time Frame: Length of ICU stay within 60 days ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who admitted ICU with hypermatebolic status, which the results of indirect calorimetry show that the actual rest energy expenditure values are remarkably higher than the predicted ones.
Criteria

Inclusion Criteria:

  • Older than 18 year.
  • APACHEⅡ score≥8

Exclusion Criteria:

  • Hypercortisolism
  • Thyroid disease
  • Tracheoesophageal fistula
  • FiO2>60 or PEEP>12cm H2O in mechanical ventilate
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02002676


Locations
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China, Jiangsu
Nanjing University School of Medicine Recruiting
Nanjing, Jiangsu, China, 210093
Contact: Chao Wu, Ph.D.    008615005171483    wuchao0008@126.com   
Sponsors and Collaborators
Nanjing University School of Medicine
Jinling Hospital, China
Investigators
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Study Director: Xinying Wang, MD Nanjing University School of Medicine
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Responsible Party: Chao Wu, Ph.D.candidate, Nanjing University School of Medicine
ClinicalTrials.gov Identifier: NCT02002676    
Other Study ID Numbers: 2013KLY-022
First Posted: December 6, 2013    Key Record Dates
Last Update Posted: June 13, 2014
Last Verified: June 2014
Keywords provided by Chao Wu, Nanjing University School of Medicine:
rest energy expenditure,critical ill, outcome
Additional relevant MeSH terms:
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Shock, Septic
Sepsis
Infection
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes
Shock