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Jugular Venous Flow Healthy Volunteers

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ClinicalTrials.gov Identifier: NCT02002494
Recruitment Status : Completed
First Posted : December 5, 2013
Results First Posted : June 4, 2020
Last Update Posted : June 4, 2020
Sponsor:
Information provided by (Responsible Party):
Lashmi Venkatraghavan, University Health Network, Toronto

Brief Summary:
Our hypothesis is that there will be a decrease in internal jugular venous flow in the park bench position when compared to the supine position. There will also be a change in blood flow in the between right and left internal jugular veins in park bench position, particularly there will be a greater reduction of flow on the dependent side. However, the internal jugular venous flow will be the same in both the prone and supine position.

Condition or disease Intervention/treatment
Jugular Venous Blood Flow Other: Different positions

Detailed Description:

The different positions used in neurosurgery (park bench, prone) for better accessibility to the operating field can impact on the cerebral venous drainage due to the effects of internal jugular venous outflow of blood and may increase intracranial pressure. The kinking of the internal jugular vein due to excessive neck flexion and rotation in park bench or flexion in the prone position may lead to kinking or twisting of the vein. This has been hypothesized as the major cause of disturbed venous drainage during surgery and in postoperative patients may lead to neck swelling, brachial plexus injury, macroglossia (swollen tongue), delayed airway obstruction and increases in intracranial pressure.

Optimal brain perfusion is best in the neutral position of the head, but surgery cannot always be performed with this. Thus, we look to measure the internal jugular venous flow at different positions as there have been little studies looking at this important contributing factor.

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Study Type : Observational
Actual Enrollment : 27 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effect of Different Surgical Positions on the Cerebral Venous Drainage: an Ultrasound Study on Healthy Volunteers
Study Start Date : June 2013
Actual Primary Completion Date : February 2014
Actual Study Completion Date : February 2014

Group/Cohort Intervention/treatment
volunteers in different positions

The following will be compared in the same volunteer:

  • Bilateral internal jugular venous flow in supine and prone position
  • Bilateral internal jugular venous flow in supine and park bench position
  • Bilateral internal jugular venous flow in prone and park bench
Other: Different positions
Jugular venous blood flow in healthy volunteers in 3 different positions- supine, prone and park bench




Primary Outcome Measures :
  1. Internal Jugular Venous (IJV) Cross Sectional Area [ Time Frame: 1 day ]
    Comparisons of both jugular vein (IJV) of twenty-seven volunteers in supine and prone positions.

  2. Right and Left IJV Cross Sectional Area [ Time Frame: 1 day ]
    Twenty-seven volunteers were included in this study. Comparisons of cross sectional area measurements in both IJVs between supine and right park bench

  3. Internal Jugular Venous (IJV) Doppler Velocity [ Time Frame: 1 day ]
    27 volunteers enrolled to measure the Internal Jugular Venous (IJV) in supine and prone positions

  4. Bilateral Internal Jugular Vein (IJV) Flow [ Time Frame: 1 day ]
    Comparisons of bilateral internal jugular vein (IJV) flow between supine and prone position. Data presented as mean (SD) .

  5. Bilateral Internal Jugular Vein (IJV) Doppler Velocity [ Time Frame: 1 day ]
    Comparisons of bilateral internal jugular vein (IJV) Doppler velocity between supine and right park bench position.

  6. R IJV and L IJV Flow [ Time Frame: 1 day ]
    Bilateral internal jugular vein (IJV) flow between supine and right park bench position.



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy Volunteers
Criteria

Inclusion Criteria:

  • Adult healthy volunteers who are above the age of 18
  • American Society of Anesthesiologists classification (ASA) 1
  • Body mass index (BMI) less than and equal to 35

Exclusion Criteria:

  • ASA 2 and above
  • BMI above 35
  • Lack of informed consent
  • Language barrier
  • Medical students and anaesthesia residents going through the department as part of their rotation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02002494


Locations
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Canada, Ontario
University Health Network, Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8
Sponsors and Collaborators
University Health Network, Toronto
Investigators
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Principal Investigator: Lashmi Venkatraghavan University Health Network, Toronto Western Hospital
Principal Investigator: Vincent Chan University Health Network, Toronto Western Hospital
Principal Investigator: Pirjo Manninen University Health Network, Toronto Western Hospital
Principal Investigator: Audrey MY Tan University Health Network, Toronto Western Hospital
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Responsible Party: Lashmi Venkatraghavan, Dr., University Health Network, Toronto
ClinicalTrials.gov Identifier: NCT02002494    
Other Study ID Numbers: 13-6244-BE
First Posted: December 5, 2013    Key Record Dates
Results First Posted: June 4, 2020
Last Update Posted: June 4, 2020
Last Verified: May 2020