Postprandial Blood Cell Transcriptome of Normal Weight and Obese Subjects to 3 Caloric Doses of a High-fat Meal
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ClinicalTrials.gov Identifier: NCT01995110 |
Recruitment Status :
Completed
First Posted : November 26, 2013
Last Update Posted : April 24, 2014
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Obesity Nutritional Intervention | Other: high-fat meal A Other: high-fat meal B Other: high-fat meal C | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 14 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Official Title: | Identification of Nutritional Health Biomarkers for Metabolic Flexibility in Blood - a Randomized, Postprandial, Caloric Dose-response Strategy |
Study Start Date : | March 2011 |
Actual Primary Completion Date : | August 2012 |
Actual Study Completion Date : | November 2013 |
Arm | Intervention/treatment |
---|---|
Experimental: normal weight subjects |
Other: high-fat meal A
Other Name: high-fat meal consisting of 500 kcal Other: high-fat meal B Other Name: high-fat meal B consisting of 1000 kcal Other: high-fat meal C Other Name: high-fat meal C consisting of 1500 kcal |
Experimental: obese subjects |
Other: high-fat meal A
Other Name: high-fat meal consisting of 500 kcal Other: high-fat meal B Other Name: high-fat meal B consisting of 1000 kcal Other: high-fat meal C Other Name: high-fat meal C consisting of 1500 kcal |
- blood cell transkriptome/ gene-expression [ Time Frame: 0h, 2h, 4h, 6h ]
- differently expressed genes between normal weight and obese subjects at baseline
- changes in gene-expression 2, 4 and 6h after consumption

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Ages Eligible for Study: | 25 Years to 50 Years (Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria for normal weight subjects:
- age 25-50
- 20<BMI>25
- waist circumference <94cm
Inclusion Criteria for obese subjects:
- age 25-50
- 30<BMI>40
- waist circumference >102cm
Exclusion Criteria for both groups:
- physiological or psychological diseases
- allergies to food or intolerance to high-fat meal
- vegetarians, vegans
- chronic intake of drugs
- smokers
- diabetes mellitus type I and II
- debiliating kidney disease
- debiliating liver disease
- clinically established coronary heart diseases
- ingestion of vitamins or dietary supplements during the course of the study

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01995110
Switzerland | |
Agroscope | |
Berne, Switzerland, CH-3003 | |
University Hospital Inselspital Berne | |
Berne, Switzerland, CH-3010 |
Principal Investigator: | Guy Vergeres, PhD | Agroscope Liebefeld-Posieux Research Station ALP | |
Study Director: | Doreen Gille, M.Sc. | Agroscope Liebefeld-Posieux Research Station ALP | |
Study Director: | Kurt Laederach, MD | Inselspital University of Berne |
Responsible Party: | Agroscope Liebefeld-Posieux Research Station ALP |
ClinicalTrials.gov Identifier: | NCT01995110 |
Other Study ID Numbers: |
NUTRICHIP-1-transcriptome |
First Posted: | November 26, 2013 Key Record Dates |
Last Update Posted: | April 24, 2014 |
Last Verified: | April 2014 |