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Construction-LBD (Constructional Apraxia in Alzheimer's Disease (AD) and Lewy Body's Dementia (LBD))

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01993628
Recruitment Status : Unknown
Verified November 2013 by University Hospital, Strasbourg, France.
Recruitment status was:  Recruiting
First Posted : November 25, 2013
Last Update Posted : November 25, 2013
Information provided by (Responsible Party):
University Hospital, Strasbourg, France

Brief Summary:

Alzheimer's disease (AD) and Lewy body's dementia (LBD) are two frequent neurodegenerative pathologies. They differ in their expression, their evolution but share same features which make their diagnosis uneasy.

Constructional apraxia has been described in both disease.The underlying mechanisms have been less studied and could be different in AD and LBD.

The definition of the constructional apraxia is purely descriptive and few models are inconclusive.

It is admitted that drawing tasks involve visuo-perceptive and visuo-spatial abilities, executive functions and working memory as well as purely "constructive" skills.

Regarding to different studies, visuo-perceptive abilities are more severely impaired in LBD than in AD and are considered as an early onset sign of the disease.

Executive functions deficits are documented in AD and LDB and could contribute to the drawing impairment.

It is possible to compensate the planning disorders in giving patient the best strategy to use.

If drawing impairment persists, they should result of others mechanisms like visuo-perception, visuo-spatial or constructive deficits.

The investigators suggest that giving the best planning strategy will help more AD patients who are supposed to fail in raison of an executive impairment, than the LDB group who is supposed to present visuo-perceptive deficits. An MRI will be proposed to study the cerebral areas involved in constructional apraxia.

Condition or disease Intervention/treatment Phase
Alzheimer's Disease Lewy Body's Dementia Other: Rey figure test Other: MRI Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 80 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Constructional Apraxia in Alzheimer's Disease (AD) and Lewy Body's Dementia (LBD)
Study Start Date : October 2013
Estimated Primary Completion Date : November 2016
Estimated Study Completion Date : November 2016

Arm Intervention/treatment
Experimental: Alzheimer's disease (AD)
Rey figure test and MRI
Other: Rey figure test
Other: MRI
Experimental: Lewy body's dementia (LBD)
Rey figure test and MRI
Other: Rey figure test
Other: MRI

Primary Outcome Measures :
  1. Score obtained at the Rey figure test with a planning strategy help by LBD patients compared to the score obtained by AD patients. [ Time Frame: At inclusion ]

Information from the National Library of Medicine

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Ages Eligible for Study:   45 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Alzheimer's disease or Lewy bodies dementia
  • ≥ 45 years
  • the cognitive impairment is mild to moderate
  • French speaker
  • a caregiver is present
  • An informed consent is signed by the patient and the p.i.

Exclusion Criteria:

  • MRI contraindication
  • Other neurological disease (FTD, brain tumor, vascular disease…)
  • Psychiatric disease (Schizophrenia, major depression, psychotic disorders, melancholia…)
  • Patient who doesn't want to be informed in case of the discovery of an abnormality
  • View or audition deficits, or motor disability which can interfere with the cognitive testing
  • Patient participating to an exclusive protocol or in the period of exclusion
  • Pregnant woman
  • Person under an administrative or legal measure of liberty privation
  • Person under a legal measure of protection or under administrative supervision
  • Person unable to give his consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01993628

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Contact: Xavier DE PETIGNY, Docteur 3 88 11 56 24 ext 0033
Contact: PHILLIPPS Clelie, Ingenior 3 88 12 79 25 ext 0033

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Hôpitaux Universitaires de Strasbourg Recruiting
Strasbourg, France
Contact: Xavier De Pétigny, Docteur    3 88 12 79 25 ext 0033   
Sponsors and Collaborators
University Hospital, Strasbourg, France
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Responsible Party: University Hospital, Strasbourg, France Identifier: NCT01993628    
Other Study ID Numbers: 5565
First Posted: November 25, 2013    Key Record Dates
Last Update Posted: November 25, 2013
Last Verified: November 2013
Additional relevant MeSH terms:
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Alzheimer Disease
Lewy Body Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Psychomotor Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Parkinsonian Disorders
Basal Ganglia Diseases
Movement Disorders