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Trial record 3 of 7702 for:    Area Under Curve

Effect of Timing of a Post-exercise Oral Glucose Tolerance Test on Glycaemic Control.

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ClinicalTrials.gov Identifier: NCT01987687
Recruitment Status : Suspended (Lack of funding)
First Posted : November 19, 2013
Last Update Posted : August 29, 2014
Sponsor:
Information provided by (Responsible Party):
Javier Gonzalez, PhD, Northumbria University

Brief Summary:

Postprandial glycaemic control is an important risk factor for the development of type 2 diabetes, cardiovascular disease and all-cause mortality.

Previous research has demonstrated that exercise performed in the postprandial state paradoxically results in a deterioration in glucose tolerance in the immediate post-exercise period (Gonzalez et a. 2013; Gonzalez and Stevenson 2013). This study aims to assess the timecourse of this post-exercise effect.


Condition or disease Intervention/treatment Phase
Area Under Curve [N06.850.520.830.200] Behavioral: Exercise Behavioral: Rest Behavioral: Delay Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Effect of Timing of a Post-exercise Oral Glucose Tolerance Test on Glycaemic Control.
Study Start Date : November 2016
Estimated Primary Completion Date : February 2017
Estimated Study Completion Date : April 2017

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Active Comparator: Rest
Breakfast followed by a rest period prior to OGTT.
Behavioral: Rest
Rest for 30 min

Experimental: Exercise-immediate
Breakfast followed by exercise and an immediate OGTT
Behavioral: Exercise
Exercise at 55% of maximum power output for 30 min.

Experimental: Exercise-delay
Breakfast followed by exercise and a delayed (1 h) OGTT.
Behavioral: Exercise
Exercise at 55% of maximum power output for 30 min.

Behavioral: Delay
Delay between exercise and OGTT




Primary Outcome Measures :
  1. Postprandial glucose concentration area under the curve [ Time Frame: 90 min ]
    Blood glucose concentrations will be sampled every 15 min following an oral glucose tolerance test.


Secondary Outcome Measures :
  1. Postprandial insulin concentration area under the curve [ Time Frame: 90 min ]
    Insulin concentrations will be determine every 15 min following an oral glucose tolerance test.



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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Normal weight (18-25 kg/m2)
  • Physically active (>or= 3 times per week)
  • Male

Exclusion Criteria:

  • Contraindications to exercise
  • Food intolerances
  • Food allergies

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01987687


Locations
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United Kingdom
Northumbria University
Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 8ST
Sponsors and Collaborators
Northumbria University
Investigators
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Principal Investigator: Javier T Gonzalez, PhD Northumbria University