A Prospective Analysis of Biofilm in Urinary Catheters Study
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To analyze biofilm obtained from at least 10 Subjects who have an indwelling catheter. A 30cc urine sample would also be collected from the same subject, and analyzed.
Condition or disease
After obtaining informed consent, concurrent with the changing of the Foley catheter in the clinic, would be obtaining a 30 cc. sample of urine which would also be fast frozen and stored in a -81 degree freezer until shipped to the Venter clinic on dry ice.
To analyze biofilm obtained from at least 10 Subjects who have an indwelling catheter. [ Time Frame: Over a period of 20 weeks ]
the proteomics, metabolomics and metagenomics ("omics") data will be analyzed and integrated in order to understand the microbial population dynamics and the interactions with the human subject host responses which may include antibacterial defenses, local inflammation, immune tolerance towards bacteria
Biospecimen Retention: Samples Without DNA
A 30cc urine sample would also be collected, along with the used catheter. The molecular evaluation will be looking specifically at the biofilm accumulated on the catheter surface. The technologies to be used are proteomics, metabolomics and metagenomics.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Subjects who require a standard foley catheter.
Subject must be 18 years of age.
Subject is attending weekly office visits at SW Wound Care Center as an out- patient.
Subject must have an indwelling Foley catheter.
Subject is informed about the trial, understands its nature of the study and provides written informed consent prior to study enrollment.
Subject is willing and able to comply with all specified care and visit requirements.
1. Subject refuses to participate in the study. 2. Subject is expected to be non-compliant. 3. Subject is a resident in a nursing home, or institutionalized. 4. Subject is pregnant. 5. Subject has a Legally Authorized Representative