The Acute Effect of Interval-walking (acute IWS)
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|ClinicalTrials.gov Identifier: NCT01987258|
Recruitment Status : Completed
First Posted : November 19, 2013
Last Update Posted : February 27, 2014
Four months of interval walking training (IWT) is superior to energy-expenditure matched continuous walking training (CWT) with regards to weight loss and improvements in glycemic control. The reason for this is unclear. One potential explanation for the differential outcome in weight loss is excess post-exercise oxygen consumption (EPOC), which is defined as the elevated oxygen consumption measured during the hours following an exercise bout. A large EPOC means greater energy expenditure which, if energy intake does not change, leads to a greater weight loss. This weight loss may subsequently improve glycemic control
- Aim 1: To assess the effect of an acute bout of IWT vs. an acute bout of CWT on glycemic control in type 2 diabetics and to assess mechanisms responsible for differences (if any). It is hypothesised that IWT will be more advantageous for improving glycemic control.
- Aim 2: To examine the effect of an acute bout of IWT vs. an acute bout of CWT on EPOC. It is hypothesised that IWT will produce an EPOC of larger magnitude than CWT.
|Condition or disease||Intervention/treatment||Phase|
|Type 2 Diabetes Mellitus||Behavioral: Interval Walking Behavioral: Continuous walking||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||10 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Acute Effect of Interval-walking|
|Study Start Date :||June 2013|
|Actual Primary Completion Date :||January 2014|
|Actual Study Completion Date :||February 2014|
No Intervention: Control
No exercise (control experiment)
Experimental: Interval Walking
A one hour interval walking exercise bout
Behavioral: Interval Walking
Experimental: Continuous walking
A one hour continuous walking exercise bout
Behavioral: Continuous walking
- Glycemic control [ Time Frame: Will be assessed immediately after the intervention using a mixed meal tolerance test (duration: 5 hours) followed by continuous glucose monitoring (duration: 48 hours). ]Glycemic control will be assessed after a one hour specific exercise intervention (control/continuous walking/interval walking) in a controlled setting (a mixed meal tolerance test). Moreover, glycemic control will be assessed during the following 2 days in a free-living environment, using continuous glucose monitoring systems.
- Excess post-exercise oxygen consumption (EPOC) [ Time Frame: Will be assessed immediately after the intervention using a ventilated hood (duration: 5 hours). ]EPOC will be assessed during the hours following the before-mentioned specific exercise bouts using the indirect calorimetry ventilated hood technique.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01987258
|Centre of Inflammation and Metabolism (CIM), Rigshospitalet, Tagensvej 20, section M7641|
|Copenhagen, Denmark, 2100|
|Principal Investigator:||Kristian Karstoft, MD||Centre of Inflammation and Metabolism (CIM), Rigshospitalet, Tagensvej 20, section M7641, DK-2100 Copenhagen, Denmark|