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International Cancer of the Head and Neck, Genetics and Environment (InterCHANGE) Study (InterCHANGE)

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ClinicalTrials.gov Identifier: NCT01972802
Recruitment Status : Unknown
Verified October 2013 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : October 30, 2013
Last Update Posted : October 30, 2013
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital

Brief Summary:
Our overall objective is to understand the role of lifestyle factors, genetics and HPV infection in the development and prognosis of head and neck cancer particularly in Asia.

Condition or disease
Evaluate the Association Between Certain Environmental Exposures (e.g. Cigarette Smoking, Alcohol Drinking, Betel Nut Chewing…) and Head and Neck Cancers Assess the Effect of Genetic Factors, Including Both SNP and Copy Number Variation (CNV) Through Analysis of Both Main Effect and Gene-gene Interaction

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Study Type : Observational
Estimated Enrollment : 900 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: International Cancer of the Head and Neck, Genetics and Environment (InterCHANGE) Study
Study Start Date : January 2011
Estimated Primary Completion Date : December 2014
Estimated Study Completion Date : December 2014

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. head and neck cancer risk factor [ Time Frame: Four years ]
    evaluate the association between certain environmental exposures (e.g. cigarette smoking, alcohol drinking, betel nut chewing…) and head and neck cancers,assess the effect of genetic factors, including both SNP and copy number variation (CNV) through analysis of both main effect and gene-gene interaction


Biospecimen Retention:   Samples With DNA
BLOOD 20ML, Fresh (biopsy)samples, Oral scrape


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
NTUH HEAD AND NECK PATIENT AND CONTROLS
Criteria

Inclusion Criteria:

Age 18~80 Incident head and neck cancer patients

  • Oral, oropharynx and hypopharynx (C00-C14)
  • Laryngreal cancer (C32)
  • *Esophageal cancer if possible (C15)

Exclusion Criteria:

  • Salivary gland (C07-C08)
  • Nasopharynx (C11)
  • Thyroid (C79.3)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01972802


Contacts
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Contact: Pei-Jen Lou +886-23123456 ext 65224 pjlou@ntu.edu.tw

Locations
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Taiwan
National Taiwan University Hospital Recruiting
Tiapei, Taipei, Taiwan, 100
Contact: Pei-Jen Lou    (02)23123456 ext 65224    pjlou@ntu.edu.tw   
Principal Investigator: Pei-Jen Lou         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
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Principal Investigator: Pei-Jen Lou National Taiwan University Hospital

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Responsible Party: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT01972802     History of Changes
Other Study ID Numbers: 201006077R
First Posted: October 30, 2013    Key Record Dates
Last Update Posted: October 30, 2013
Last Verified: October 2013

Keywords provided by National Taiwan University Hospital:
HEAD AND NECK

Additional relevant MeSH terms:
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Head and Neck Neoplasms
Alcohol Drinking
Neoplasms by Site
Neoplasms
Drinking Behavior