Working...
ClinicalTrials.gov
ClinicalTrials.gov Menu

Clinical Characteristics and Microbiology of Healthcare Associated Pneumonia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01966796
Recruitment Status : Completed
First Posted : October 22, 2013
Last Update Posted : October 22, 2013
Sponsor:
Information provided by (Responsible Party):
Ping-Huai Wang, Far Eastern Memorial Hospital

Brief Summary:

Background The prediction of multi-drug resistant (MDR) pathogens is a key issue in the management of health-care associated pneumonia (HCAP). Multiple risk factors have been proposed, some of which overlap with items of the pneumonia severity index (PSI). The aim of this study was to investigate the relationship between PSI and presence of MDR pathogens.

Methods Patients who were admitted to a tertiary-care hospital from January 2005 to December 2010 were screened by a discharge diagnosis of pneumonia. Patients were enrolled if they fulfilled the definition of HCAP by 2005 ATS/IDSA guideline.


Condition or disease
Healthcare Associated Pneumonia

Detailed Description:

MDR bacteria were defined as Pseudomonas aeruginosa (P. aeruginosa), Enterobacter species, those not sensitive to second and third generation cephalosporins, Acinetobacter species, extended-spectrum β-lactamase (ESBL) Enterobacteriaceae such as Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae), Burkholderia cepacia (B. cepacia), Stenotrophomonas maltophilia (S. maltophilia), and methicillin resistant Staphylococcus aureus (MRSA).

The criteria for HCAP is defined as follows: patients who had been hospitalized in an acute care hospital for two or more days within the past 90 days; residents of a nursing home or long-term care facility; recipients of recent intravenous antibiotic therapy, chemotherapy or wound care within the past 30 days; or patients who attended a hospital or hemodialysis clinic.


Layout table for study information
Study Type : Observational
Actual Enrollment : 530 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Clinical Characteristics and Microbiology of Healthcare Associated Pneumonia
Study Start Date : February 2013
Actual Primary Completion Date : October 2013
Actual Study Completion Date : October 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pneumonia

Group/Cohort
PSI II
PSI less than 70 or equal to 70
PSI III
PSI 70-90
PSI IV
PSI 90-130
PSI V
PSI more than 130



Primary Outcome Measures :
  1. pathogens of healthcare associated pneumonia [ Time Frame: upto seven days ]
    sputum culture and sterile specimen such as blood or pleural effusion culture for healthcare associated pneumonia within seven days of admission



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients who were admitted to the Far Eastern Memorial Hospital, an 800-bed tertiary care hospital in northern Taiwan, from January 2005 to December 2010 were screened by discharge diagnoses.The patients whose primary discharge diagnosis was pneumonia (International Classification of Diseases codes 482, 485, and 486) were selected.
Criteria

Inclusion Criteria:

  • patients who had been hospitalized in an acute care hospital for two or more days within the past 90 days;
  • residents of a nursing home or long-term care facility;
  • recipients of recent intravenous antibiotic therapy, chemotherapy or wound care within the past 30 days;
  • or patients who attended a hospital or hemodialysis clinic.

Exclusion Criteria:

-


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01966796


Locations
Layout table for location information
Taiwan
Far Eastern Memorial Hospital
New Taipei, Taiwan, 220
Sponsors and Collaborators
Far Eastern Memorial Hospital
Investigators
Layout table for investigator information
Principal Investigator: Ping-huai Wang, M.D. Far Eastern Memorial Hospital

Publications:

Layout table for additonal information
Responsible Party: Ping-Huai Wang, Medical Dr, Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier: NCT01966796     History of Changes
Other Study ID Numbers: 102013-E
First Posted: October 22, 2013    Key Record Dates
Last Update Posted: October 22, 2013
Last Verified: October 2013

Keywords provided by Ping-Huai Wang, Far Eastern Memorial Hospital:
healthcare associated pneumonia
drug-resistant bacteria
pneumonia severity index

Additional relevant MeSH terms:
Layout table for MeSH terms
Healthcare-Associated Pneumonia
Pneumonia
Lung Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Cross Infection
Infection
Iatrogenic Disease
Disease Attributes
Pathologic Processes