Imaging and Genetic Investigation of Learning and Decision Making
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|ClinicalTrials.gov Identifier: NCT01950377|
Recruitment Status : Completed
First Posted : September 25, 2013
Last Update Posted : March 11, 2020
- Previous research has shown that dopamine, a brain chemical, is involved in decision making. Different genes influence how much dopamine people have in their brains and how that affects their behavior. Researchers will study if genes associated with dopamine affect decision making and impulsiveness. All participants will take tests; some will have brain images taken. Researchers will study the test responses and images; they will look for how differences in these genes affect different types of decision making.
- To see if genes involved in a brain chemical, dopamine, are related to impulsiveness on behavioral tests.
- Healthy adults ages 18 to 55.
- Participants will be screened with a medical history and physical exam.
- All participants in this study will have at least 1 outpatient visit to the NIH Clinical Center. Each visit will last 2 4 hours. At the first visit:
- A blood sample will be taken only from participants that have not been previously enrolled in 95-M-0150
- Participants will be given tests of their memory, attention, concentration, and thinking.
- Some participants will have a second visit. It will be scheduled as soon as possible after the first. At the second visit:
- Participants will have an MRI (magnetic resonance imaging). They will have to lie in a scanner for up to 2 hours. The MRI uses magnets, radio waves, and computers to produce detailed pictures of the brain.
- Participants will repeat the tests from the first visit. Some will be done during the MRI.
|Condition or disease|
|Polymorphism- Genetic Reward Mediating System|
|Study Type :||Observational|
|Actual Enrollment :||78 participants|
|Official Title:||Imaging and Genetic Investigation of Learning and Decision Making|
|Actual Study Start Date :||February 11, 2014|
|Actual Primary Completion Date :||February 12, 2018|
|Actual Study Completion Date :||March 5, 2020|
Healthy adults healthy adults - male and female
- Outcome measures include performance in the behavioral tasks, effects in the magnetic resonance imaging data, and the genotype of individual participants. [ Time Frame: ongoing ]Outcome measures include performance in the behavioral tasks, effects in the magnetic resonance imaging data, and the genotype of individual participants.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01950377
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Bruno B Averbeck, Ph.D.||National Institute of Mental Health (NIMH)|