Remifentanil Use in Pediatric Rigid Bronchoscopy
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|ClinicalTrials.gov Identifier: NCT01947114|
Recruitment Status : Completed
First Posted : September 20, 2013
Last Update Posted : September 20, 2013
Purpose: In this study we wanted to compare bolus propofol and ketamine as an adjuvant to remifentanil-based total intravenous anesthesia for pediatric rigid bronchoscopy.
Materials and Methods: Forty children under 12 years of age scheduled for rigid bronchoscopy were included. After midazolam premedication, remifentanil infusion 1 µg/kg/min was started and patients were randomly allocated to receive either propofol (Group P) or ketamine (Group K) and mivacurium for muscle relaxation. Anesthesia was maintained with remifentanil infusion 1 µg/kg/min and bolus doses of propofol or ketamine. After rigid bronchoscopy remifentanil 0.05 µg/kg/min was maintained until extubation. Hemodynamic parameters, emergence characteristics and adverse events were evaluated.
|Condition or disease||Intervention/treatment||Phase|
|Pediatric Rigid Bronchoscopy||Drug: Propofol Drug: Ketamine Drug: Remifentanil||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||40 participants|
|Official Title:||Remifentanil-based Total Intravenous Anesthesia for Pediatric Rigid Bronchoscopy: Comparison of Propofol and Ketamine As Adjuvant|
|Study Start Date :||November 2005|
|Actual Primary Completion Date :||August 2006|
|Actual Study Completion Date :||August 2006|
|Active Comparator: Group Propofol||
|Active Comparator: Group Ketamine||
- Change in systolic arterial pressure [ Time Frame: Systolic arterial pressure was assessed before anesthesia induction (baseline), 2 minutes after anesthesia induction, at 1., 3., 6., 9., 12., and 15. minutes of rigid bronchoscopy. ]Noninvasive systolic blood pressure was measured with 3 minutes of interval during rigid bronchoscopy. The duration of rigid bronchoscopy was 10-15 minutes.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01947114
|Bezmialem Vakif University Faculty of Medicine|
|Istanbul, Turkey, 34093|