Working...
ClinicalTrials.gov
ClinicalTrials.gov Menu

A New Approach to Measuring Energy Expenditure in Humans

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01938794
Recruitment Status : Completed
First Posted : September 10, 2013
Last Update Posted : September 25, 2017
Sponsor:
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by (Responsible Party):
University of Colorado, Denver

Brief Summary:
Accurately measuring how many calories a person burns each day is difficult to do. Researchers can do this with a technique called doubly labeled water (DLW). This involves drinking water that is "labeled" with a non-radioactive tracer. After a few hours, the labeled water can be detected in the urine. To measure how many calories are burned (Total daily energy expenditure, TDEE), urine samples are collected several days apart. Although this technique is accurate, it is also challenging for two reasons. First, the labeled water is expensive. Second, the urine samples are analyzed using equipment (Isotope Ratio Mass Spectrometer, or IRMS) that is expensive and difficult to operate. The goal of this project is to develop a new instrument to perform DLW measurements of TDEE. This instrument, called a triple isotope water analyzer (TIWA) is less expensive and easier to operate than IRMS. Additionally, since the TIWA is more accurate than IRMS, it may potentially reduce the amount of labeled water required to measure TDEE, and thus reduce costs. The purpose of this study is to compare the accuracy of measuring TDEE from labeled water using the new instrument (TIWA) and from the traditional approach (IRMS). We will also compare the accuracy to the measurement of TDEE from whole-room indirect calorimetry (metabolic room), which is considered the most accurate way to measure TDEE.

Condition or disease
Human Energy Expenditure

  Show Detailed Description

Layout table for study information
Study Type : Observational
Actual Enrollment : 72 participants
Observational Model: Other
Time Perspective: Cross-Sectional
Official Title: Improvements to the Doubly Labeled Water Technique to Measure Total Daily Energy Expenditure
Study Start Date : September 2013
Actual Primary Completion Date : August 31, 2017
Actual Study Completion Date : August 31, 2017



Primary Outcome Measures :
  1. Daily energy expenditure [ Time Frame: 7 days ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years to 99 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Healthy adults (>18 yrs)
Criteria

Inclusion Criteria:

  • Age > 18yrs

Exclusion Criteria:

  • Smokers
  • weight > 300 lbs
  • chronic disease (e.g. diabetes, heart disease, thyroid disease)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01938794


Locations
Layout table for location information
United States, Colorado
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Sponsors and Collaborators
University of Colorado, Denver
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
Layout table for investigator information
Principal Investigator: Edward L Melanson, PhD University of Colorado, Denver

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Layout table for additonal information
Responsible Party: University of Colorado, Denver
ClinicalTrials.gov Identifier: NCT01938794     History of Changes
Other Study ID Numbers: 13-1497
R44DK093362 ( U.S. NIH Grant/Contract )
First Posted: September 10, 2013    Key Record Dates
Last Update Posted: September 25, 2017
Last Verified: September 2017