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Exercise and Branched Chain Amino Acids (BCAA)Requirements in Older Men

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ClinicalTrials.gov Identifier: NCT01931722
Recruitment Status : Suspended (not able to find enough participants for this study)
First Posted : August 29, 2013
Last Update Posted : January 12, 2016
Sponsor:
Information provided by (Responsible Party):
Peter Lemon, University of Western Ontario, Canada

Study Description
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Brief Summary:
Likely, branched chain amino acid (BCAA) requirements are increased in older strength-trained (ST) individuals. If so, supplementation in this group will maximize muscle protein synthesis (MPS) and minimize loss of muscle with age (sarcopenia).

Condition or disease Intervention/treatment Phase
Sarcopenia Dietary Supplement: Branched chain amino acid Behavioral: Strength training Not Applicable

Detailed Description:
We hypothesize that the dietary requirement for the branched chain amino acids (BCAA) in an older strength-trained (ST) population will be greater than the current recommendation (RDA). If so, a greater intake of BCAA together with ST is necessary if one aims to maximize muscle protein synthesis (MPS). Currently, the BCAA requirement in the ST older population (55-65 y) is unknown. This is critical information especially given the value of ST for overall health.
Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 6 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Can Branched Chained Amino Acid Supplementation Combined With Strength-Training Minimize Sarcopenia in Older Men?
Study Start Date : January 2016
Estimated Primary Completion Date : December 2016
Estimated Study Completion Date : December 2016

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Arms and Interventions
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Arm Intervention/treatment
Active Comparator: Branched chain amino acid
Branched chain amino acid as food supplement
 Dietary Supplement: Branched chain amino acid
seven graded intakes of a BCAA (branched chain amino acid) mixture from 50 to 350 mg.kg-1.d-1 will be used to measure BCAA requirement
Other Name: Ajinomoto branched chain amino acids

Behavioral: Strength training
Strength training will include a split-training program using all major muscle groups of the body on a three day "on", one day "off" protocol. Muscle areas targeted on each training day will be as follows: Day1: chest, shoulder, triceps; Day2: back, biceps; Day3: legs and calfs; Day4: will be a rest day. On Day5: this cycle will begin again. A combination of free weights and machines will be used for each training day. Progressive overload protocol will be applied where the load used by every participant will be adjusted bi-weekly based on their 70% of 1 repetition maximum (maximum weight that can be lifted only one time). Instruction will be provided for all exercises and professional trainers will oversee all training sessions.
Other Name: weight training
Active Comparator: Weight training
Strength training will include a split-training program using all major muscle groups of the body on a three day "on", one day "off" protocol. Muscle areas targeted on each training day will be as follows: Day1: chest, shoulder, triceps; Day2: back, biceps; Day3: legs and calfs; Day4: will be a rest day. On Day5: this cycle will begin again. A combination of free weights and machines will be used for each training day. Progressive overload protocol will be applied where the load used by every participant will be adjusted bi-weekly based on their 70% of 1RM (repetition maximum). Instruction will be provided for all exercises and professional trainers will oversee all training sessions.
 Dietary Supplement: Branched chain amino acid
seven graded intakes of a BCAA (branched chain amino acid) mixture from 50 to 350 mg.kg-1.d-1 will be used to measure BCAA requirement
Other Name: Ajinomoto branched chain amino acids

Behavioral: Strength training
Strength training will include a split-training program using all major muscle groups of the body on a three day "on", one day "off" protocol. Muscle areas targeted on each training day will be as follows: Day1: chest, shoulder, triceps; Day2: back, biceps; Day3: legs and calfs; Day4: will be a rest day. On Day5: this cycle will begin again. A combination of free weights and machines will be used for each training day. Progressive overload protocol will be applied where the load used by every participant will be adjusted bi-weekly based on their 70% of 1 repetition maximum (maximum weight that can be lifted only one time). Instruction will be provided for all exercises and professional trainers will oversee all training sessions.
Other Name: weight training


Outcome Measures
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Primary Outcome Measures :
  1. Required Branched chain amino acid of older strength trained men [ Time Frame: 12 months ]
    Branched chain amino acid requirement will be measured in 55-65 years old strength trained men using indicator amino acid oxidation method


Secondary Outcome Measures :
  1. Muscle size [ Time Frame: 12 months ]
    cross-sectional measure of muscle size will be measured in all participants using standard procedures of magenetic resonance imaging


Eligibility Criteria
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Ages Eligible for Study:   55 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Recreationally active (~2-3 h/wk of physical activity) healthy older men (55-65 y)
  • A minimum of 4 month weight training experience

Exclusion Criteria:

  • Have symptoms or take medication for respiratory disease
  • Have symptoms or take medication for cardiovascular disease
  • Have symptoms or take medication for metabolic disease
  • Have symptoms or take mediation for neuromuscular disease
  • Use heart rate or blood pressure medications
  • Use any medications with side effects of dizziness, lack of motor control, or slowed reaction time
  • Have an excessive alcohol intake (more than 2 drinks per day)
  • Have any cardiovascular or neuromuscular limitations to exercise
  • Are allergic to milk or milk products
  • Use anabolic steroids or performance enhancing drugs
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01931722


Locations
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Canada, Ontario
Exercise Nutrition Research Laboratory
London, Ontario, Canada, N6A 5B9
Sponsors and Collaborators
University of Western Ontario, Canada
Investigators
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Principal Investigator: Peter Lemon, PhD The University of Western Ontario
Study Director: Arash Bandegan, MSc. The University of Western Ontario
More Information
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Publications:

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Responsible Party: Peter Lemon, Professor and Weider Research Chair, University of Western Ontario, Canada
ClinicalTrials.gov Identifier: NCT01931722    
Other Study ID Numbers: 002
First Posted: August 29, 2013    Key Record Dates
Last Update Posted: January 12, 2016
Last Verified: January 2016
Keywords provided by Peter Lemon, University of Western Ontario, Canada:
branched chain amino acid requirement
older men
strength training
sarcopenia
Additional relevant MeSH terms:
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Sarcopenia
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
 Nervous System Diseases
Atrophy
Pathological Conditions, Anatomical