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Anti-inflammatory Effect of Aerobic Exercise in Individual With Increased Cardiovascular Risk

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ClinicalTrials.gov Identifier: NCT01903941
Recruitment Status : Completed
First Posted : July 19, 2013
Last Update Posted : July 19, 2013
Sponsor:
Information provided by (Responsible Party):
Luis CL Correia, Escola Bahiana de Medicina e Saude Publica

Brief Summary:
Aerobic physical activity attenuates systemic inflammatory activity in individuals with cardiovascular risk.

Condition or disease Intervention/treatment Phase
Inflammation Behavioral: Aerobic Exercise Behavioral: Only Counseling Phase 2

Detailed Description:

Background: Observational studies suggest that exercise has anti-inflammatory effect, however this idea has not been definitively confirmed by randomized clinical trials.

Objective: To test the hypothesis that aerobic exercise attenuates systemic inflammatory activity in individuals with cardiovascular risk.

Methods: Randomized controlled trial, which included 68 sedentary individuals, with at least two risk factors for coronary heart disease or established cardiovascular disease. The volunteers were randomized to 3 months of supervised aerobic training or just advice when healthy lifestyles. C-reactive protein (CRP) was measured by the method of high sensitivity before and after 3 months of intervention.


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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 68 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Anti-inflammatory Effect of Aerobic Exercise in Individual With Increased Cardiovascular Risk
Study Start Date : December 2006
Actual Primary Completion Date : April 2008
Actual Study Completion Date : April 2008

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Training
Aerobic
Behavioral: Aerobic Exercise
Placebo Comparator: Control
Not exercise
Behavioral: Only Counseling



Primary Outcome Measures :
  1. C-reactive protein [ Time Frame: 3 months ]


Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

- Individuals with are between 40 to 70 years, no regular exercise, and at least two risk factor for cardiovascular disease (diabetes, hypertension, dyslipidemia, smoking) or documented cardiovascular disease.

Exclusion Criteria:

- Incapacity to exercise.


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Responsible Party: Luis CL Correia, Associate Professor of Medicine, Escola Bahiana de Medicina e Saude Publica
ClinicalTrials.gov Identifier: NCT01903941     History of Changes
Other Study ID Numbers: CRPExercise
First Posted: July 19, 2013    Key Record Dates
Last Update Posted: July 19, 2013
Last Verified: July 2013

Keywords provided by Luis CL Correia, Escola Bahiana de Medicina e Saude Publica:
exercise

Additional relevant MeSH terms:
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Inflammation
Pathologic Processes
Anti-Inflammatory Agents