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Determination of the Nature of the Endogenous Ligand of TREM-1 and Its Use as a New Diagnostic Biomarker in Sepsis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01903668
Recruitment Status : Withdrawn
First Posted : July 19, 2013
Last Update Posted : July 19, 2013
Information provided by (Responsible Party):
Centre Hospitalier Universitaire Dijon

Brief Summary:
Step 1: Identification and characterisation of the TREM1L protein from samples already available characterised at the hospital Central of Nancy Step 2: Study of the isoforms of TREM1L in correlation with the prognosis of sepsis, Step 3: implementation of assay methods for TREM1L (ELISA or SUPRA MS) Step 4: Validation of assays for TREM1L and its isoforms in a larger number of subjects (inclusion of samples from Dijon CHU and Besançon CHU)

Condition or disease

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Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Cohort
Time Perspective: Retrospective
Study Start Date : April 2012
Estimated Primary Completion Date : April 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sepsis

Primary Outcome Measures :
  1. plasma concentrations of sTREM-1 [ Time Frame: baseline ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Blood samples used for this study come from a collection being created as part of the research entitled "The combined determination STREM-1/PCT/CD64 it allows the diagnosis of sepsis in intensive care" - No. IDRCB 2009 - A00870-57 and led by Professor Sebastian GIBOT CHU Nancy.

Inclusion Criteria:

  • patients hospitalised in a Medical Intensive Care unit whatever the reason
  • written informed consent obtained

Exclusion Criteria:

  • patients less than 18 years old or under guardianship, persons without national health insurance.
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Responsible Party: Centre Hospitalier Universitaire Dijon Identifier: NCT01903668    
Other Study ID Numbers: Ducoroy PHRC IR 2012
First Posted: July 19, 2013    Key Record Dates
Last Update Posted: July 19, 2013
Last Verified: July 2013
Additional relevant MeSH terms:
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Systemic Inflammatory Response Syndrome
Pathologic Processes