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Interference With Cognitive Control by Transcranial Direct Current Stimulation

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ClinicalTrials.gov Identifier: NCT01903538
Recruitment Status : Completed
First Posted : July 19, 2013
Last Update Posted : July 19, 2013
Sponsor:
Information provided by (Responsible Party):
Christian Plewnia, MD, University Hospital Tuebingen

Brief Summary:

Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit. In this study the investigators assess the effect of a decrease of dlPFC activity in healthy subjects by cathodal transcranial direct current stimulation (tDCS) on cognitive control.

In a double-blinded, balanced randomized, sham-controlled crossover trial the investigators determine the effect of a single-session of cathodal tDCS to the left dlPFC on cognitive control in healthy subjects. To assess the cognitive control the investigators use a delayed response working memory task (DWM)and an arithmetic inhibition task (AIT) with pictures of varying valence.


Condition or disease Intervention/treatment Phase
Depression Device: Cathodal transcranial direct current stimulation (tDCS) Device: Sham transcranial direct current stimulation Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 28 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Study Start Date : July 2011
Actual Primary Completion Date : July 2012
Actual Study Completion Date : July 2012

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Arm Intervention/treatment
Experimental: Cathodal transcranial direct current stimulation Device: Cathodal transcranial direct current stimulation (tDCS)
Cathodal transcranial direct current stimulation (tDCS) 20min, 1mA, F3 (EEG 10/20), reference right M. deltoideus

Sham Comparator: Sham transcranial direct current stimulation Device: Sham transcranial direct current stimulation
Sham transcranial direct current stimulation (tDCS) 40s, 1mA, F3 (EEG 10/20), reference right M. deltoideus




Primary Outcome Measures :
  1. Correctness and reaction time of response [ Time Frame: Within 30 min starting 5 min after the initiation of stimulation ]
    Correctness is defined as the percentage of correct responses in the DWM and AIT



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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

informed consent

Exclusion Criteria:

psychiatric or neurological disorders seizures cardiac pacemakers


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01903538


Locations
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Germany
Department of Psychiatry and Psychotherapy, University of Tübingen
Tübingen, Germany, 72076
Sponsors and Collaborators
University Hospital Tuebingen

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Responsible Party: Christian Plewnia, MD, Professor, University Hospital Tuebingen
ClinicalTrials.gov Identifier: NCT01903538     History of Changes
Other Study ID Numbers: 211/2010BO1_2
First Posted: July 19, 2013    Key Record Dates
Last Update Posted: July 19, 2013
Last Verified: July 2013

Additional relevant MeSH terms:
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Depression
Behavioral Symptoms