Comparison of Intraneural and Extraneural Young's Modulus Using Shear Wave Elastography
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|ClinicalTrials.gov Identifier: NCT01903369|
Recruitment Status : Completed
First Posted : July 19, 2013
Last Update Posted : May 6, 2019
|Condition or disease||Intervention/treatment|
|Regional Anaesthesia||Device: Shear Wave Elastography|
Shear wave elastography is a quantitative ultrasound modality increasingly used to differentiate between "hard" breast cancer masses and "soft" normal tissue. Unlike strain elastography, shear wave elastography applies a non-compressive longitudinal acoustic radiation force to underlying tissues, inducing transverse shear waves. Studies in Thiel embalmed human cadavers have shown significant differences in Young's modulus between intraneural and extraneural tissue, and ready colour differentiation between tissues.
The investigators own pilot studies have shown a 3-fold greater Young's modulus within nerve in Thiel embalmed cadavers and human volunteers. The investigators hypothesis is that shear wave elastography can differentiate between nerve and adjacent tissue in patients before nerve block for surgery. If so, this technology has the potential to reduce the incidence of complications with UGRA and encourage parallel applications such as cancer node biopsy.
|Study Type :||Observational|
|Actual Enrollment :||47 participants|
|Official Title:||Comparison of Intraneural and Extraneural Young's Modulus Using Shear Wave Elastography in Patients Undergoing Regional Anaesthesia|
|Actual Study Start Date :||September 25, 2014|
|Actual Primary Completion Date :||March 26, 2015|
|Actual Study Completion Date :||July 10, 2015|
Elective orthopaedic surgery patients
All patients presenting for elective orthopaedic surgery >16 years of age.
Device: Shear Wave Elastography
Shear wave elastography
Other Name: Siemens 3000 shear wave utrasound machine
- The difference in stiffness between nerves and surrounding tissue in patients when using shear wave measurement before regional anaesthesia. [ Time Frame: One visit per patient 45 mins ]Youngs modulus
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01903369
|Department of Anaesthesia, Ninewells Hospital & Medical School|
|Dundee, United Kingdom, DD19SY|
|Principal Investigator:||Graeme A McLeod, MBChB FRCA||NHS Tayside|