Modulation of Dyspnea Perception During Exercise in COPD Patients Using Attentional Distraction (DVD)
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|ClinicalTrials.gov Identifier: NCT01902927|
Recruitment Status : Unknown
Verified July 2013 by Philippe Gagnon, PhD Candidate, Laval University.
Recruitment status was: Not yet recruiting
First Posted : July 18, 2013
Last Update Posted : July 18, 2013
Chronic obstructive pulmonary disease (COPD) is a major health problem whose prevalence is increasing rapidly. The gradual decrease in exercise tolerance is one of the usual consequences of COPD that affects the functional independence and quality of life of patients.
In COPD patients, breathlessness and muscle fatigue are the main symptoms limiting exercise. Recent studies have shown that most of the physiological mechanisms of psychological factors such as emotions, motivation, memory, personality, expectations, or prior experience can greatly influence and modulate the perception of breathlessness. It has been proposed that the attentional distraction (visual or auditory) during exercise may be associated with a decrease in anxiety and shortness of breath and could improve exercise tolerance in COPD. We therefore propose to study the impact of attentional strategies of distraction on the perception of dyspnea and walking tolerance in patients with COPD.
The research hypotheses are:
i) Compared with exposure to a strategy of negative attentional distraction during exercise, exposure to a strategy of positive attentional distraction will improve walking exercise tolerance in patients with COPD;
ii) For a given level of effort, sensory perception and emotional perception will be enhanced by exposure to a strategy of positive attentional distraction.
Ten subjects with moderate to severe COPD will be recruited at the Research Center of the Institut Universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ). During an assessment visit, we will measure complete pulmonary function, body composition and maximal functional capacity during a maximal incremental test work performed on a treadmill.
During two subsequent experimental visits, and after spirometry control, participants will perform a walking test performed on a treadmill at an intensity corresponding to 75% of maximum effort during maximal incremental test. The test will be carried out in combination with a strategy of either positive attentional distraction, neutral attentional distraction or negative attentional distraction . The order of the condition will be randomized.
|Condition or disease||Intervention/treatment||Phase|
|Chronic Obstructive Pulmonary Disease||Other: Attentional distraction using IAPS protocol (standardized images)||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||10 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Modulation of Dyspnea Perception During Exercise in COPD Patients Using Attentional Distraction : a Pilot Study|
|Study Start Date :||July 2013|
|Estimated Primary Completion Date :||October 2013|
|Estimated Study Completion Date :||October 2013|
Experimental: COPD patients
COPD patients will perform a constant workrate treadmill exercise test until exhaustion with positve/neutral/negative visual distraction images during the exercise test assigned in a randomized order
Other: Attentional distraction using IAPS protocol (standardized images)
Positive, Negative and Neutral Attentional distraction will be presented using IAPS protocol (standardized images) during exercise tests
- Exercise tolerance [ Time Frame: During each experimental visit (V2-V3-V4), from the start to the end of the exercise test (limited by symptoms of the patients). Participants will be followed for an expected period of 3 weeks (from date of randomization to the completion of the study) ]The exercise tolerance (sec) will be defined as the time to exhaustion following a standardized constant workrate treadmill walking test corresponding to 75 % of maximal workload previously determined.
- Dyspnea perception [ Time Frame: During visit 2-3-4, from start to end of the endurance exercise test at every 90-sec intervals, up to 20 minutes. Participants will be followed for an expected period of 3 weeks (from date of randomization to the completion of the study) ]The dyspnea intensity will be measured using a 10-point Borg scale during the exercise test
- Dyspnea affective perception [ Time Frame: During visit 2-3-4, from start to end of the endurance exercise test at every 90-sec intervals, up to 20 minutes. Participants will be followed for an expected period of 3 weeks (from date of randomization to the completion of the study) ]The affective perception of dyspnea will be measured using the mutlidimensionnal dyspnea profile questionnaire (MDP), graded on a 10-point scale
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01902927
|Contact: Philippe Gagnon, PhD||418-656-8711 ext firstname.lastname@example.org|
|Contact: Didier Saey, PhD||418-656-8711 ext email@example.com|
|Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ)||Not yet recruiting|
|Québec, Quebec, Canada, G1V 4G5|
|Contact: Philippe Gagnon, PhD 418-656-8711 ext 2672 firstname.lastname@example.org|
|Contact: Didier Saey, PhD 418-656-8711 ext 2614 email@example.com|
|Principal Investigator: François Maltais, MD|
|Principal Investigator:||François Maltais, MD||Centre de recherche - Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)|