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Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men

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ClinicalTrials.gov Identifier: NCT01888991
Recruitment Status : Completed
First Posted : June 28, 2013
Last Update Posted : June 28, 2013
Sponsor:
Collaborator:
Canadian Institutes of Health Research (CIHR)
Information provided by (Responsible Party):
G. Harvey Anderson, University of Toronto

Brief Summary:
The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

Condition or disease Intervention/treatment Phase
Food Intake Regulation Substrate Oxidation Other: Glucose Preload and Exercise Intervention Not Applicable

Detailed Description:

The relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake is undefined. This study is examining the effects of three modulators of substrate oxidation (RER), a glucose preload, exercise and age food intake regulation and net energy balance in normal-weight boys (9-12 y) and men (20-30 y).

Subjects (15 boys, 15 men) were measured in random order with treatments of beverages of either water or glucose followed by either moderate exercise or rest for 40 min. Measures included RER via indirect calorimetry, energy expenditure, subjective appetite, food intake measured at an ad libitum pizza meal and net energy balance as the sum of the calories of the glucose preload + calories from the pizza lunch minus energy expended at exercise or rest.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Prevention
Official Title: Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men.
Study Start Date : December 2011
Actual Primary Completion Date : August 2012
Actual Study Completion Date : August 2012

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
No Intervention: water with resting condition
Experimental: glucose with resting condition Other: Glucose Preload and Exercise Intervention
A glucose preload and exercise were administered to examine the modulate substrate oxidation

Experimental: water with exercise condition Other: Glucose Preload and Exercise Intervention
A glucose preload and exercise were administered to examine the modulate substrate oxidation

Experimental: glucose with exercise condition Other: Glucose Preload and Exercise Intervention
A glucose preload and exercise were administered to examine the modulate substrate oxidation




Primary Outcome Measures :
  1. Food Intake [ Time Frame: 60 - 90 min in the study ]
    Energy intake from the ad libitum the pizza meal at 60 min was calculated based on the weight consumed and the compositional information provided by the manufacturer.


Secondary Outcome Measures :
  1. Net Energy Balance [ Time Frame: 0-90 min in the study ]
    Will be calculated from the energy consumed by the glucose preload and the pizza meal minus energy expended at the exercise.



Information from the National Library of Medicine

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Ages Eligible for Study:   9 Years to 29 Years   (Child, Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Born at full term
  • Men Age:20-29 years/BMI: 20-25
  • Boys Age 9-11/BMI percentile: 15th to 85th:

Exclusion Criteria:

  • Smokers
  • Dieters
  • Individuals with lactose intolerance, allergies to milk and dairy products
  • Individuals with gastrointestinal problems
  • Individuals with diabetes or other metabolic diseases
  • Individuals scoring ≥ 11 on an Eating Habit Questionnaire

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01888991


Locations
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Canada, Ontario
Department of Nutritional Sciences, University of Toronto
Toronto, Ontario, Canada, M5S 3E2
Sponsors and Collaborators
University of Toronto
Canadian Institutes of Health Research (CIHR)
Investigators
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Principal Investigator: Harvey Anderson, Ph.D. University of Toronto
Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: G. Harvey Anderson, Professor, University of Toronto
ClinicalTrials.gov Identifier: NCT01888991    
Other Study ID Numbers: CIHR kids_26570
CIHR MOP-111250 ( Other Grant/Funding Number: 111250 )
First Posted: June 28, 2013    Key Record Dates
Last Update Posted: June 28, 2013
Last Verified: June 2013
Keywords provided by G. Harvey Anderson, University of Toronto:
Glucose
Exercise
Metabolic flexibility
Substrate Oxidation
Food intake