Influence of tDCS on Cortical Plasticity in Patients With Mild Cognitive Impairment (MCI)
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ClinicalTrials.gov Identifier: NCT01888029 |
Recruitment Status :
Withdrawn
(Not funded)
First Posted : June 27, 2013
Last Update Posted : May 14, 2021
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Patients With Mild Cognitive Impairment | Device: transcranial direct current stimulation Device: sham stimulation | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 0 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Investigator) |
Primary Purpose: | Treatment |
Official Title: | Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Patients With Mild Cognitive Impairment (MCI) |
Study Start Date : | May 2013 |
Estimated Primary Completion Date : | October 2017 |
Estimated Study Completion Date : | December 2017 |
Arm | Intervention/treatment |
---|---|
Experimental: transcranial direct current stimulation |
Device: transcranial direct current stimulation |
Placebo Comparator: sham stimulation |
Device: sham stimulation |
- the anodal transcranial direct current stimulation over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) [ Time Frame: 1 week ]to investigate whether the anodal transcranial direct current stimulation over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) increases cortical plasticity (measured via motor evoked potentials) compared to sham stimulation
- Comparison of tDCS-induced changes on central cholinergic activity [ Time Frame: 1 week ]to investigate weather the anodal transcranial direct current stimulation affect central cholinergic activity (measured via a TMS protocol) in MCI patients compared to sham stimulation
- Comparison of tDCS-induced changes in learning success [ Time Frame: 1 week ]tDCS-induced changes in learning success (performance in a motor learning paradigm in patients with MCI after tDCS vs. sham stimulation)
- MR elastography [ Time Frame: 1 week ]Comparison of viscoelastic parameters in cerebral MR elastography in patients with MCI
- genetic polymorphism, ApoE4 [ Time Frame: once ]optional assessment of genetic Apo4 epsilon status for assessment of differences in cortical plasticity and elasticity between Apo4 epsilon positive and negative participants

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Ages Eligible for Study: | 50 Years to 80 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Right-handed according to the Oldfield Händigkeits inventory (lateralization index> 70) (1971)
- Cognitive impairment according to the diagnostic criteria of a MCI (amnesic or even multiple domains)
- No therapeutic treatment with AChE inhibitors
- No motor impairments relevant to everyday life
- Age 50 to 80 years
Exclusion Criteria:
- Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
- Epilepsy, epileptic seizure in medical history
- Cognitive deficit (MMSE <20)
- Depressive episode (Beck Depression Inventory (BDI)> 12)
- Newly taking (<3 months) centrally active drugs, particularly acetylcholinesterase inhibitors
- Pregnancy
- Pacemaker (contraindication for MRI)
- Other metal parts in the body (contraindication for MRI)

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01888029
Germany | |
Klinik und Poliklinik für Neurologie, Charité Universitätsmedizin Berlin | |
Berlin, Germany, 10117 |
Responsible Party: | Agnes Flöel, Prof. Dr., Charite University, Berlin, Germany |
ClinicalTrials.gov Identifier: | NCT01888029 |
Other Study ID Numbers: |
Plasticity in MCI |
First Posted: | June 27, 2013 Key Record Dates |
Last Update Posted: | May 14, 2021 |
Last Verified: | May 2021 |
mild cognitive impairment Transcranial Direct Current Stimulation Cortical Plasticity |
Cognitive Dysfunction Cognition Disorders Neurocognitive Disorders Mental Disorders |