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Study of Opioid Immunosuppressive Effects

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ClinicalTrials.gov Identifier: NCT01881802
Recruitment Status : Unknown
Verified June 2013 by Xiaohong Long, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University.
Recruitment status was:  Enrolling by invitation
First Posted : June 20, 2013
Last Update Posted : June 20, 2013
Sponsor:
Information provided by (Responsible Party):
Xiaohong Long, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Brief Summary:
This trial aims to investigate the effects of opioid-inducing immune suppression on opioid drug abused patients. The methods of the investigators research mainly includes the expression of morphine-related miRNAs in peripheral blood mononuclear cells and cytokine in plasma.

Condition or disease
Opioid Abuse or Dependence

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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Study Start Date : March 2013
Estimated Primary Completion Date : June 2013

Group/Cohort
morphine or heroin dependence patients
normal control group



Primary Outcome Measures :
  1. real-time quantitative polymerase chain reaction [ Time Frame: up to 2 months ]

Secondary Outcome Measures :
  1. enzyme-linked immuno sorbent assay [ Time Frame: up to 2 months ]

Biospecimen Retention:   Samples With DNA
The refrigerator - 80 degrees


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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Guangzhou Psychiatric Hospital
Criteria

Inclusion Criteria:

  • subjects were excluded if they had a chronic systemic illness (cardiac, renal, pulmonary, hepatic, endocrine, metabolic, or autoimmune disorders) or
  • a major psychiatric disorder or
  • if they were abusing substances other than heroin (as determined by urine drug test result). For women, pregnancy was also a reason for exclusion.

Exclusion Criteria:

  • Control subjects with no history of drug or alcohol abuse were also excluded if they had
  • major medical or psychiatric disorders

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Responsible Party: Xiaohong Long, doctoral candidate, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
ClinicalTrials.gov Identifier: NCT01881802     History of Changes
Other Study ID Numbers: 01
First Posted: June 20, 2013    Key Record Dates
Last Update Posted: June 20, 2013
Last Verified: June 2013
Keywords provided by Xiaohong Long, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University:
Opioid drug Abuse
Morphine
Immune Function
Additional relevant MeSH terms:
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Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Morphine
Analgesics, Opioid
Narcotics
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics
Sensory System Agents
Peripheral Nervous System Agents