Postoperative Neuroinflammation and Cognitive Dysfunction After Abdominal Surgery (POPE)
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|ClinicalTrials.gov Identifier: NCT01881646|
Recruitment Status : Completed
First Posted : June 19, 2013
Last Update Posted : January 11, 2017
|Condition or disease||Intervention/treatment||Phase|
|Anesthesia Surgery Neurogenic Inflammation Cognitive Disorders||Radiation: Positron emission tomography (PET) using [11C]PBR28||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||8 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Study Start Date :||June 2013|
|Actual Primary Completion Date :||February 2016|
|Actual Study Completion Date :||February 2016|
Experimental: Positron emission tomography (PET)
Positron emission tomography (PET) using [11C]PBR28
Radiation: Positron emission tomography (PET) using [11C]PBR28
- Binding of the PET probe [11C]PBR28 [ Time Frame: Preoperatively, once at postoperative day 2-5 and after 3 month ]PET imaging of brain regions of relevance for memory and learning will be compared between the pre- and postoperative states.
- Cognitive testing [ Time Frame: Preoperatively and after 3 month ]Postoperative cognitive test battery according to the ISPOCD protocol, see Moller JT et al, Lancet 1998.
- Inflammatory biomarkers [ Time Frame: Preoperatively, once at postoperative day 2-5 and after 3 month, i.e. at the same time as the PET investigation ]Inflammatory biomarkers and genetic analysis of inflammatory biomarkers in blood.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01881646
|Principal Investigator:||Lars I Eriksson, MD,PhD, Professor||Karolinska University Hospital and Karolinska Institutet|