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Lung Sonography in Patients With Acute Respiratory Distress Syndrome in Intensive Care Unit

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01881061
Recruitment Status : Completed
First Posted : June 19, 2013
Last Update Posted : June 19, 2013
Information provided by (Responsible Party):
Serafim Nanas, University of Athens

Brief Summary:
The purpose of this study is to evaluate the role of lung sonography during different PEEP settings in ICU patients with ARDS.

Condition or disease

Detailed Description:

Acute respiratory distress syndrome (ARDS) is a clinical syndrome that often occurs in critically ill patients.

Patients with ARDS invariably require mechanical ventilation to improve oxygen transport. An improvement in oxygenation can be obtained by an increase in positive end-expiratory pressure (PEEP).

In critically ill patients with ARDS, lung imaging is been held by the use of chest radiography and the "gold standard" technique, Computed Tomography (CT).

We designed an observational study in which we included patients under mechanical ventilation admitted in our ICU. In all patients PEEP changes were applied and lung sonography was performed.

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Study Type : Observational
Actual Enrollment : 10 participants
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : September 2009
Actual Primary Completion Date : December 2011
Actual Study Completion Date : December 2011

Primary Outcome Measures :
  1. Non aerated lung area changes [ Time Frame: 20 min after PEEP trial ]

Secondary Outcome Measures :
  1. Arterial oxygen and carbon dioxide partial pressure [ Time Frame: 20 min after PEEP trial ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
ICU population

Inclusion Criteria:

  • Critically ill patients with ARDS admitted in ICU of Evangelismos Hospital
  • length of stay > 48 hours

Exclusion Criteria:

  • age < 18 years
  • emphysema fractures or skin lesions that do not allow the implementation of lung sonography
  • BMI > 35 kg/m2
  • length of stay < 48 hours

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01881061

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First Critical Care Unit, Evaggelismos Hospital, School of Medicine, University of Athens
Athens, Attiki, Greece, 10676
Sponsors and Collaborators
University of Athens
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Study Chair: Serafim Nanas, MD University of Athens

Publications of Results:
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Responsible Party: Serafim Nanas, Professor of Critical Care Medicine, University of Athens Identifier: NCT01881061     History of Changes
Other Study ID Numbers: UOA-US-2010
First Posted: June 19, 2013    Key Record Dates
Last Update Posted: June 19, 2013
Last Verified: June 2013
Keywords provided by Serafim Nanas, University of Athens: