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Role of ASICs in Human Inflammatory Pain

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01867840
Recruitment Status : Unknown
Verified October 2016 by Centre Hospitalier Universitaire de Nice.
Recruitment status was:  Recruiting
First Posted : June 4, 2013
Last Update Posted : October 21, 2016
Information provided by (Responsible Party):
Centre Hospitalier Universitaire de Nice

Brief Summary:
In recent years, ion channels have emerged as new therapeutic targets for pain. Among these channels, ASICs (Acid Sensing Ion Channels) are of particular interest because they are directly activated by extracellular acidity, which is a major cause of pain. Indeed, many painful conditions such as ischemia, inflammation, tumor development or tissue incision are accompanied by tissue acidification. ASIC are excitatory ion channels that are expressed in neurons, including nociceptive sensory neurons. In humans, the use of amiloride, a nonspecific inhibitor of ASICs, has demonstrated their role in the perception of pain induced by subcutaneous injections of acidic solutions. ASICs thus appear as new candidates capable of mediating pain in humans. A growing number of data suggests that, in addition to protons, ASICs may also be activated by one or more endogenous compounds produced during inflammation. The purpose of this research project is to identify these compounds by testing the effects of human inflammatory exudates on ASICs activity. The discovery of such compounds would definitely validate ASICs as novel therapeutic targets for pain treatment in humans

Condition or disease
Arthritis Osteoarthritis Chondrocalcinosis Gouty Arthritis Rheumatoid Arthritis

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Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Cohort
Official Title: Study of the Role of Acid Sensing Ion Channels (ASICs) in Human Inflammatory Pain
Study Start Date : November 2012
Actual Primary Completion Date : December 2014
Estimated Study Completion Date : December 2018

Resource links provided by the National Library of Medicine


Primary Outcome Measures :
  1. activation or miodulation to Electrical potential of ionic channel in the synovial fluid [ Time Frame: 1 day ]
    only once because it's an single ponction of sinovial fluid.

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
(osteoarthritis, chondrocalcinosis, gouty arthritis, rheumatoid arthritis)

Inclusion Criteria:

  • septic arthritis
  • gonarthrosis in push-inflammatory
  • microcrystalline arthropathies
  • chronic inflammatory rheumatism

Exclusion Criteria:

  • refusal to participate in the protocol

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01867840

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Contact: Véronique BREUIL, Pr 0492035512

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Service de Rhumatologie Recruiting
Nice, France, 06000
Contact: Véronique BREUIL, Pr    0492035512   
Sub-Investigator: Emmanuel DEVAL, PhD         
Sponsors and Collaborators
Centre Hospitalier Universitaire de Nice
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Principal Investigator: Véronique BREUIL, Pr service de rhumatologie
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Responsible Party: Centre Hospitalier Universitaire de Nice Identifier: NCT01867840    
Other Study ID Numbers: 12-PP-07
First Posted: June 4, 2013    Key Record Dates
Last Update Posted: October 21, 2016
Last Verified: October 2016
Additional relevant MeSH terms:
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Arthritis, Gouty
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Crystal Arthropathies
Purine-Pyrimidine Metabolism, Inborn Errors
Metabolism, Inborn Errors
Genetic Diseases, Inborn
Metabolic Diseases