Adaptation to Living With a BRCA1/2 Mutation
|ClinicalTrials.gov Identifier: NCT01866865|
Recruitment Status : Completed
First Posted : June 3, 2013
Last Update Posted : April 5, 2018
- Women who have a BRCA1/2 gene mutation have a very high risk of developing breast or ovarian cancer. They are also at increased risk of other developing other cancers. Male carriers are at increased risk for breast, prostate and other cancers. Testing for this mutation and living with this increased risk can be a source of stress for both people with the mutation and their partners. Researchers want to look at how well people adapt to living with this type of cancer risk over time.
- To see how women with the BRCA1/2 gene mutation and their partners adapt to the stress of long-term cancer risk.
- Women at least 18 years of age who have a BRCA1/2 mutation, and their male or female partners.
- This study involves a one-time self-administered questionnaire. Participants will be recruited from local and national hereditary cancer support groups and cancer centers.
- There are two versions of the survey. One is for the woman with the BRCA1/2 gene mutation. The other is for her partner.
- The survey will ask about risk perception, cancer worry, risk-related stress, and coping and adaptation methods.
- Treatment will not be provided as part of this study.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||142 participants|
|Official Title:||Adaptation to Living With a BRCA l/2 Mutation in Carriers and Their Partners|
|Study Start Date :||May 2, 2013|
|Actual Primary Completion Date :||February 20, 2014|
|Actual Study Completion Date :||February 20, 2014|
- the primary outcome is psychological adaptation [ Time Frame: 1 time survey ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01866865
|United States, Maryland|
|Johns Hopkins Bloomberg School of Public Health|
|Baltimore, Maryland, United States|
|Principal Investigator:||Barbara B Biesecker||National Human Genome Research Institute (NHGRI)|