Early Retinal Nerve Fiber Layer Change of Ethambutol Optic Neuropathy by Optical Coherence Tomography
|ClinicalTrials.gov Identifier: NCT01866579|
Recruitment Status : Completed
First Posted : May 31, 2013
Last Update Posted : May 20, 2014
Ethambutol is widely used as first-line drug, but has serious side effect of optic neuropathy. As previously reported, incidence of ethambutol optic neuropathy is about 1~2%, there was considerable screening efforts and medical cost is increasing. However, there is no effective treatment of ethambutol optic neuropathy or no definite preventable measure. Moreover, multi-drug resistance tuberculosis or extensively drug resistance tuberculosis is emerging, more toxic secondary drug is used in the long-term.
It is known that retinal nerve fiber layer is increased early stage in ethambutol optic neuropathy. So we decide to evaluate the retinal nerve fiber layer thickness measured by optical coherence tomography in longitudinal manner.
|Condition or disease|
|Primary Lung Tuberculosis|
|Study Type :||Observational|
|Actual Enrollment :||49 participants|
|Study Start Date :||May 2013|
|Actual Primary Completion Date :||May 2014|
|Actual Study Completion Date :||May 2014|
|ethambutol optic neuropathy|
- Change in Retinal Nerve Fiber Layer thickness measured by optical coherence tomography [ Time Frame: Early Retinal Nerve Fiber Layer change of initial before anti-tuberculosis treatment, 4 months after anti-tuberculosis treatment, 6 months after anti-tuberculosis treatmen ]Retinal Nerve Fiber Layer is axon of the retinal ganglion cell. It can be measured by optical coherence tomography. It is non-invasive and good reproducibility method to measure retinal nerve fiber layer in vivo.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01866579
|Korea, Republic of|
|Department of Ophthalmology, Gangnam Severance Hospital|
|Seoul, Korea, Republic of, 146-92|